J
Jian-Min Chen
Researcher at French Institute of Health and Medical Research
Publications - 199
Citations - 8041
Jian-Min Chen is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Pancreatitis & Gene. The author has an hindex of 46, co-authored 195 publications receiving 7155 citations. Previous affiliations of Jian-Min Chen include University of Western Brittany & Université catholique de Louvain.
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Journal ArticleDOI
Gene conversion: mechanisms, evolution and human disease
TL;DR: Current thinking about how gene conversion occurs is assessed, the key part it has played in fashioning extant human genes is explored, and a meta-analysis of gene-conversion events that are known to have caused human genetic disease is carried out.
Journal ArticleDOI
Type of PKD1 mutation influences renal outcome in ADPKD.
Emilie Cornec-Le Gall,Marie-Pierre Audrézet,Marie-Pierre Audrézet,Jian-Min Chen,Jian-Min Chen,Maryvonne Hourmant,M.P. Morin,Régine Perrichot,Christophe Charasse,Bassem Whebe,E. Renaudineau,P. Jousset,Marie-Paule Guillodo,Anne Grall-Jezequel,Philippe Saliou,Philippe Saliou,Claude Férec,Claude Férec,Yannick Le Meur +18 more
TL;DR: It is confirmed that renal survival associated with PKD2 mutations was approximately 20 years longer than that associated withPKD1 mutations, and the type of PKD1 mutation, but not its position, correlated strongly with renal survival.
Journal ArticleDOI
Variants in CPA1 are strongly associated with early onset chronic pancreatitis
Heiko Witt,Sebastian Beer,Jonas Rosendahl,Jian-Min Chen,Jian-Min Chen,Giriraj R. Chandak,Atsushi Masamune,Melinda Bence,Richárd Szmola,Richárd Szmola,Grzegorz Oracz,Milan Macek,Eesh Bhatia,Sandra Steigenberger,Denise Lasher,Florence Bühler,Catherine Delaporte,Johanna Tebbing,Maren Ludwig,Claudia Pilsak,Karolin Saum,Peter Bugert,Emmanuelle Masson,Emmanuelle Masson,Sumit Paliwal,Seema Bhaskar,Agnieszka Sobczynska-Tomaszewska,Daniel Bak,Ivan Balascak,Gourdas Choudhuri,D. Nageshwar Reddy,G Venkat Rao,Varghese Thomas,Kiyoshi Kume,Eriko Nakano,Yoichi Kakuta,Tooru Shimosegawa,Lukasz Durko,András Szabó,Andrea Schnúr,Andrea Schnúr,Péter Hegyi,Zoltán Rakonczay,Roland H. Pfützer,Alexander Schneider,David A. Groneberg,Markus Braun,Hartmut Schmidt,Ulrike Witt,Helmut Friess,Hana Algül,Olfert Landt,Markus Schuelke,Renate Krüger,Bertram Wiedenmann,Frank Schmidt,Klaus Peter Zimmer,Peter Kovacs,Michael Stumvoll,Matthias Blüher,Thomas Müller,Andreas R. Janecke,Niels Teich,Robert Grützmann,Hans Ulrich Schulz,Joachim Mössner,Volker Keim,Matthias Löhr,Claude Férec,Claude Férec,Miklós Sahin-Tóth +70 more
TL;DR: The mechanism by which CPA1 variants confer increased pancreatitis risk may involve misfolding-induced endoplasmic reticulum stress rather than elevated trypsin activity, as is seen with other genetic risk factors for this disease.
Journal ArticleDOI
A systematic analysis of LINE-1 endonuclease-dependent retrotranspositional events causing human genetic disease
TL;DR: The systematic study of these lesions, when combined with previous in vitro and genome-wide analyses, has strengthened several important conclusions regarding L1-mediated retrotransposition in humans: approximately 25% of L1 insertions are associated with the 3′ transduction of adjacent genomic sequences, and ~25% of the new L1 inserts are full-length.
Journal ArticleDOI
A degradation-sensitive anionic trypsinogen ( PRSS2 ) variant protects against chronic pancreatitis
Heiko Witt,Miklós Sahin-Tóth,Olfert Landt,Jian-Min Chen,Thilo Kähne,Joost P.H. Drenth,Zoltán Kukor,Edit Szepessy,Walter Halangk,Stefan Dahm,Klaus Rohde,Hans Ulrich Schulz,Cédric Le Maréchal,Nejat Akar,Rudolf W. Ammann,Kaspar Truninger,Mario Bargetzi,Eesh Bhatia,Carlo Castellani,Giulia Martina Cavestro,Milos Cerny,Giovanni Destro-Bisol,Gabriella Spedini,Hans Eiberg,Jan B.M.J. Jansen,Monika Koudova,Eva Rausova,Milan Macek,Núria Malats,Francisco X. Real,Hans Jürgen Menzel,Pedro Moral,Roberta Galavotti,Pier Franco Pignatti,Olga Rickards,Julius Spicak,Narcis O. Zarnescu,Wolfgang Böck,Thomas M. Gress,Helmut Friess,Johann Ockenga,Hartmut Schmidt,Roland H. Pfützer,Matthias Löhr,Peter Simon,Frank Ulrich Weiss,Markus M. Lerch,Niels Teich,Volker Keim,Thomas Berg,Bertram Wiedenmann,W Luck,David A. Groneberg,Michael Becker,Thomas Keil,Andreas Kage,Jana Bernardova,Markus Braun,Claudia Güldner,J. Halangk,Jonas Rosendahl,Ulrike Witt,Matthias Treiber,Renate Nickel,Claude Férec +64 more
TL;DR: The G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis.