D
Denise Lasher
Researcher at Technische Universität München
Publications - 4
Citations - 438
Denise Lasher is an academic researcher from Technische Universität München. The author has contributed to research in topics: Pancreatitis & Gene. The author has an hindex of 3, co-authored 4 publications receiving 349 citations.
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Journal ArticleDOI
Variants in CPA1 are strongly associated with early onset chronic pancreatitis
Heiko Witt,Sebastian Beer,Jonas Rosendahl,Jian-Min Chen,Jian-Min Chen,Giriraj R. Chandak,Atsushi Masamune,Melinda Bence,Richárd Szmola,Richárd Szmola,Grzegorz Oracz,Milan Macek,Eesh Bhatia,Sandra Steigenberger,Denise Lasher,Florence Bühler,Catherine Delaporte,Johanna Tebbing,Maren Ludwig,Claudia Pilsak,Karolin Saum,Peter Bugert,Emmanuelle Masson,Emmanuelle Masson,Sumit Paliwal,Seema Bhaskar,Agnieszka Sobczynska-Tomaszewska,Daniel Bak,Ivan Balascak,Gourdas Choudhuri,D. Nageshwar Reddy,G Venkat Rao,Varghese Thomas,Kiyoshi Kume,Eriko Nakano,Yoichi Kakuta,Tooru Shimosegawa,Lukasz Durko,András Szabó,Andrea Schnúr,Andrea Schnúr,Péter Hegyi,Zoltán Rakonczay,Roland H. Pfützer,Alexander Schneider,David A. Groneberg,Markus Braun,Hartmut Schmidt,Ulrike Witt,Helmut Friess,Hana Algül,Olfert Landt,Markus Schuelke,Renate Krüger,Bertram Wiedenmann,Frank Schmidt,Klaus Peter Zimmer,Peter Kovacs,Michael Stumvoll,Matthias Blüher,Thomas Müller,Andreas R. Janecke,Niels Teich,Robert Grützmann,Hans Ulrich Schulz,Joachim Mössner,Volker Keim,Matthias Löhr,Claude Férec,Claude Férec,Miklós Sahin-Tóth +70 more
TL;DR: The mechanism by which CPA1 variants confer increased pancreatitis risk may involve misfolding-induced endoplasmic reticulum stress rather than elevated trypsin activity, as is seen with other genetic risk factors for this disease.
Journal ArticleDOI
A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis
Karianne Fjeld,Frank Ulrich Weiss,Denise Lasher,Jonas Rosendahl,Jian-Min Chen,Jian-Min Chen,Bente B. Johansson,Bente B. Johansson,Holger Kirsten,Claudia Ruffert,Emmanuelle Masson,Solrun J. Steine,Peter Bugert,Miriam Cnop,Robert Grützmann,Julia Mayerle,Joachim Mössner,Monika Ringdal,Monika Ringdal,Hans-Ulrich Schulz,Matthias Sendler,Peter Simon,Paweł Sztromwasser,Paweł Sztromwasser,Janniche Torsvik,Janniche Torsvik,Markus Scholz,Erling Tjora,Erling Tjora,Claude Férec,Heiko Witt,Markus M. Lerch,Pål R. Njølstad,Pål R. Njølstad,Stefan Johansson,Stefan Johansson,Anders Molven,Anders Molven +37 more
TL;DR: A hybrid allele (CEL-HYB) originating from a crossover between CEL and its neighboring pseudogene, CELP is described, implicate a new pathway distinct from the protease-antiprotease system of pancreatic acinar cells in chronic pancreatitis.
Journal ArticleDOI
Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis
Denise Lasher,András Szabó,András Szabó,Atsushi Masamune,Jian-Min Chen,Xunjun Xiao,David C. Whitcomb,M. Michael Barmada,Maren Ewers,Claudia Ruffert,Sumit Paliwal,Prachand Issarapu,Seema Bhaskar,K. Radha Mani,Giriraj R. Chandak,Helmut Laumen,Emmanuelle Masson,Kiyoshi Kume,Shin Hamada,Eriko Nakano,Katharina Seltsam,Peter Bugert,Thomas Müller,David A. Groneberg,Tooru Shimosegawa,Jonas Rosendahl,Jonas Rosendahl,Claude Férec,Mark E. Lowe,Heiko Witt,Miklós Sahin-Tóth +30 more
TL;DR: It is indicated that protease-sensitive PNLIP variants are novel genetic risk factors for the development of CP.
Journal ArticleDOI
A recombination allele of the lipase gene CEL and its pseudogene CELP encodes a hybrid protein and is a genetic risk factor for chronic pancreatitis
Karianne Fjeld,Stefan Johansson,Jonas Rosendahl,Jian-Min Chen,Denise Lasher,Miriam Cnop,Bente B. Johansson,Emmanuelle Masson,Julia Mayerle,Joachim Mössner,Claudia Ruffert,Solrun J. Steine,Erling Tjora,Janniche Torsvik,Claude Férec,F. Ulrich Weiss,Heiko Witt,Markus M. Lerch,Pål R. Njølstad,Anders Molven +19 more