S
Sook Wah Yee
Researcher at University of California, San Francisco
Publications - 106
Citations - 8837
Sook Wah Yee is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Metformin & Pharmacogenomics. The author has an hindex of 39, co-authored 92 publications receiving 7468 citations. Previous affiliations of Sook Wah Yee include Cardiff University & Georgia Regents University.
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Journal ArticleDOI
Membrane transporters in drug development.
Kathleen M. Giacomini,Shiew-Mei Huang,Donald J. Tweedie,Leslie Z. Benet,Kim L. R. Brouwer,Xiaoyan Chu,Amber Dahlin,Raymond Evers,Volker Fischer,Kathleen M. Hillgren,Keith Hoffmaster,Toshihisa Ishikawa,Dietrich Keppler,Richard B. Kim,Caroline A. Lee,Mikko Niemi,Joseph W. Polli,Yuicchi Sugiyama,Peter W. Swaan,Joseph A. Ware,Stephen H. Wright,Sook Wah Yee,Maciej J. Zamek-Gliszczynski,Lei Zhang +23 more
TL;DR: Overall, it is advised that the timing of transporter investigations should be driven by efficacy, safety and clinical trial enrolment questions, as well as a need for further understanding of the absorption, distribution, metabolism and excretion properties of the drug molecule, and information required for drug labelling.
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Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing.
Mary V. Relling,Eric E. Gardner,William J. Sandborn,Kjeld Schmiegelow,C H Pui,Sook Wah Yee,Charles M. Stein,Michelle Whirl Carrillo,William E. Evans,Teri E. Klein +9 more
TL;DR: Dosing recommendations for azathioprine, mercaptopurine (MP), and thioguanine based on TPMT genotype are provided and homozygous wild‐type individuals show lower activeThiopurine nucleolides and less myelosuppression.
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SLC transporters as therapeutic targets: emerging opportunities
TL;DR: Current and investigational drugs that modulate SLC transporters, as well as promising drug targets, are highlighted.
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Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing: 2013 Update
Mary V. Relling,Eric E. Gardner,William J. Sandborn,Kjeld Schmiegelow,C H Pui,Sook Wah Yee,Charles M. Stein,Michelle Whirl Carrillo,William E. Evans,J K Hicks,Matthias Schwab,Matthias Schwab,Teri E. Klein +12 more
TL;DR: Although relevant new evidence has been generated, none of the evidence would change the primary dosing recommendations in the original guideline; therefore, the original publication remains clinically current.
Journal ArticleDOI
Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.
Ying Chen,Shuanglian Li,Chaline Brown,Stephen Cheatham,Richard A. Castro,Maya K. Leabman,Thomas J. Urban,Ligong Chen,Sook Wah Yee,Ji Ha Choi,Yong Huang,Claire M. Brett,Esteban G. Burchard,Kathleen M. Giacomini +13 more
TL;DR: It is concluded that genetic variation in OCT2 plays an important role in the CLR and SrCLR of metformin in healthy volunteers.