Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing.
Mary V. Relling,Eric E. Gardner,William J. Sandborn,Kjeld Schmiegelow,C H Pui,Sook Wah Yee,Charles M. Stein,Michelle Whirl Carrillo,William E. Evans,Teri E. Klein +9 more
TLDR
Dosing recommendations for azathioprine, mercaptopurine (MP), and thioguanine based on TPMT genotype are provided and homozygous wild‐type individuals show lower activeThiopurine nucleolides and less myelosuppression.Abstract:
Thiopurine methyltransferase (TPMT) activity exhibits monogenic co-dominant inheritance, with ethnic differences in the frequency of occurrence of variant alleles. With conventional thiopurine doses, homozygous TPMT-deficient patients (~1 in 178 to 1 in 3,736 individuals with two nonfunctional TPMT alleles) experience severe myelosuppression, 30-60% of individuals who are heterozygotes (~3-14% of the population) show moderate toxicity, and homozygous wild-type individuals (~86-97% of the population) show lower active thioguanine nucleolides and less myelosuppression. We provide dosing recommendations (updates at http://www.pharmgkb.org) for azathioprine, mercaptopurine (MP), and thioguanine based on TPMT genotype.read more
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CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network
Mary V. Relling,Teri E. Klein +1 more
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Acute lymphoblastic leukaemia.
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Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update
Kristine R. Crews,Andrea Gaedigk,Andrea Gaedigk,Henry M. Dunnenberger,J. S. Leeder,J. S. Leeder,Teri E. Klein,Kelly E. Caudle,Cyrine E. Haidar,Danny D. Shen,J T Callaghan,J T Callaghan,Senthilkumar Sadhasivam,Cynthia A. Prows,Evan D. Kharasch,Todd C. Skaar +15 more
TL;DR: This document is an update to the 2012 Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for CYP2D6 genotype and codeine therapy and provides therapeutic recommendations for codeine based on CYP1D8 genotype.
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Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?
Ching-Hon Pui,Charles G. Mullighan,William E. Evans,William E. Evans,Mary V. Relling,Mary V. Relling +5 more
TL;DR: Specific areas of research are discussed that promise to further refine current treatment and to improve the cure rate and quality of life of the patients.
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic
TL;DR: Evidence from published literature is presented for CYP 2D6 and CYP2C19 genotype–directed dosing of tricyclic antidepressants.
References
More filters
Book
A Course in Game Theory
TL;DR: A Course in Game Theory as discussed by the authors presents the main ideas of game theory at a level suitable for graduate students and advanced undergraduates, emphasizing the theory's foundations and interpretations of its basic concepts.
Book
Reasoning About Knowledge
TL;DR: Reasoning About Knowledge is the first book to provide a general discussion of approaches to reasoning about knowledge and its applications to distributed systems, artificial intelligence, and game theory.
Journal ArticleDOI
The control of discrete event systems
Peter J. Ramadge,W. M. Wonham +1 more
TL;DR: The focus is on the qualitative aspects of control, but computation and the related issue of computational complexity are also considered.
Proceedings ArticleDOI
On the synthesis of a reactive module
Amir Pnueli,Roni Rosner +1 more
TL;DR: An algorithm is presented based on a new procedure for checking the emptiness of Rabin automata on infinite trees in time exponential in the number of pairs, but only polynomial in theNumber of states, which leads to a synthesis algorithm whose complexity is doubleonential in the length of the given specification.
Journal ArticleDOI
Alternating-time temporal logic
TL;DR: This work introduces a third, more general variety of temporal logic: alternating-time temporal logic, which offers selective quantification over those paths that are possible outcomes of games, such as the game in which the system and the environment alternate moves.
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