S
Sophie Pritchard
Researcher at Wellcome Trust Sanger Institute
Publications - 12
Citations - 665
Sophie Pritchard is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Immune system & Cell type. The author has an hindex of 4, co-authored 6 publications receiving 74 citations.
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Journal ArticleDOI
Cells of the human intestinal tract mapped across space and time.
Rasa Elmentaite,Natsuhiko Kumasaka,Kenny Roberts,Aaron M. Fleming,Emma Dann,Hamish W King,Vitalii Kleshchevnikov,Monika Dabrowska,Sophie Pritchard,Liam Bolt,Sara F. Vieira,Lira Mamanova,Ni Huang,Francesca Perrone,Issac Goh Kai’En,Steven Lisgo,Matilda Katan,Steven Leonard,Thomas R. W. Oliver,Thomas R. W. Oliver,C. Elizabeth Hook,Komal Nayak,Lia S. Campos,Cecilia Domínguez Conde,Emily Stephenson,Justin Engelbert,Rachel A. Botting,Krzysztof Polanski,Stijn van Dongen,Minal Patel,Michael D Morgan,Michael D Morgan,John C. Marioni,John C. Marioni,John C. Marioni,Omer Ali Bayraktar,Kerstin B Meyer,Xiaoling He,Roger A. Barker,Holm H. Uhlig,Holm H. Uhlig,Krishnaa T. Mahbubani,Kourosh Saeb-Parsy,Matthias Zilbauer,Menna R. Clatworthy,Menna R. Clatworthy,Muzlifah Haniffa,Muzlifah Haniffa,Kylie R. James,Kylie R. James,Sarah A. Teichmann,Sarah A. Teichmann +51 more
TL;DR: The cellular landscape of the human intestinal tract is dynamic throughout life, developing in utero and changing in response to functional requirements and environmental exposures as discussed by the authors, using single-cell RNA sequencing and antigen receptor analysis of almost half a million cells from up to 5 anatomical regions of the developing and up to 11 distinct anatomical regions in the healthy human gut.
Journal ArticleDOI
Cross-tissue immune cell analysis reveals tissue-specific features in humans
Cecilia Domínguez Conde,L. Jarvis,Dan Rainbow,Steven B. Wells,Tomás Gomes,S Howlett,Ondrej Suchanek,Krzysztof Polanski,H. King,Lira Mamanova,Ni Huang,Peter A. Szabo,Laura Richardson,Liam Bolt,Eirini S. Fasouli,K. Mahbubani,M. Julieta Del Prete,Liz Tuck,Nathan Richoz,Zewen K. Tuong,Lia S. Campos,Hani S Mousa,Edward Needham,Sophie Pritchard,T. Li,Rasa Elmentaite,J. Park,Esfandiar Rahmani,David K. Menon,O. Bayraktar,L. James,K. Meyer,Nir Yosef,Menna R. Clatworthy,Peter J. Sims,Donna L. Farber,Kourosh Saeb-Parsy,J. Jones,Sarah A. Teichmann +38 more
TL;DR: An immune cell atlas of human innate and adaptive immune cells across lymphoid, mucosal, and exocrine sites reveals tissue-specific compositions and features, and reveals insights into how the immune system adapts to function effectively in different organ contexts.
Journal ArticleDOI
Single-Cell Sequencing of Developing Human Gut Reveals Transcriptional Links to Childhood Crohn's Disease.
Rasa Elmentaite,Alexander Ross,Kenny Roberts,Kylie R. James,Daniel Ortmann,Tomás Gomes,Komal Nayak,Liz Tuck,Sophie Pritchard,Omer Ali Bayraktar,Robert Heuschkel,Ludovic Vallier,Sarah A. Teichmann,Sarah A. Teichmann,Sarah A. Teichmann,Matthias Zilbauer +15 more
TL;DR: An in-depth single-cell map of the developing human intestine at 6–10 weeks post-conception is generated, revealing the transcriptional profile of cycling epithelial precursor cells; distinct from LGR5-expressing cells.
Journal ArticleDOI
Mapping the developing human immune system across organs
Chenqu Suo,Emma Dann,Issac Goh,Laura Jardine,Vitalii Kleshchevnikov,Jong-Eun Park,Rachel A. Botting,Emily Stephenson,Justin Engelbert,Zewen K. Tuong,Krzysztof Polanski,Nadav Yayon,Chuan Xu,Ondrej Suchanek,Rasa Elmentaite,Cecilia Conde,Peng He,Sophie Pritchard,Mohiuddin Miah,Corina Moldovan,Alexander S. Steemers,M. Julieta Del Prete,John C. Marioni,Menna R. Clatworthy,Muzlifah Haniffa,Sarah A. Teichmann +25 more
TL;DR: A comprehensive single-cell RNA sequencing atlas of human developing immune system is performed together with antigen-receptor sequencing and spatial transcriptomics to reconstruct the developing human immune system and identifies, characterised and functionally validated the properties of human prenatal B1 cells and the origin of unconventional T cells.
Posted ContentDOI
A spatial multi-omics atlas of the human lung reveals a novel immune cell survival niche
Elo Madissoon,Elo Madissoon,Amanda Oliver,Vitalii Kleshchevnikov,Anna Wilbrey-Clark,Krzysztof Polanski,Ana Ribeiro Orsi,Ana Ribeiro Orsi,Lira Mamanova,Liam Bolt,Nathan Richoz,Rasa Elmentaite,J. Patrick Pett,Ni Huang,Peng He,Monika Dabrowska,Sophie Pritchard,Liz Tuck,Elena Prigmore,Andrew J Knights,Agnes Oszlanczi,Adam Hunter,Sara F. Vieira,Minal Patel,Nikitas Georgakopoulos,Krishnaa T. Mahbubani,Kourosh Saeb-Parsy,Menna R. Clatworthy,Menna R. Clatworthy,Omer Ali Bayraktar,Oliver Stegle,Oliver Stegle,Natsuhiko Kumasaka,Sarah A. Teichmann,Sarah A. Teichmann,Kerstin B. Meyer +35 more
TL;DR: In this article, a multi-omics spatial lung atlas is presented to define additional heterogeneity and novel cell types which are mapped back into the macro-and micro-anatomical tissue context to define functional tissue microenvironments.