Monika Dabrowska

TL;DR: In this article, the effect of cold storage on fresh healthy spleen, esophagus, and lung from ≥ 5 donors over 72h was assessed, and robust protocols for tissue preservation for up to 24h prior to scRNA-seq analysis were presented.

TL;DR: The cellular landscape of the human intestinal tract is dynamic throughout life, developing in utero and changing in response to functional requirements and environmental exposures as discussed by the authors, using single-cell RNA sequencing and antigen receptor analysis of almost half a million cells from up to 5 anatomical regions of the developing and up to 11 distinct anatomical regions in the healthy human gut.

TL;DR: In this paper, the authors dissect the signaling pathways that determine cell fate of the epithelial lineages in the lumenal and glandular microenvironments of the endometrium.

TL;DR: In this article, a multi-omics spatial lung atlas is presented to define additional heterogeneity and novel cell types which are mapped back into the macro-and micro-anatomical tissue context to define functional tissue microenvironments.

TL;DR: In this paper, the authors dissect the signalling pathways that determine cell fate of the epithelial lineages in the lumenal and glandular microenvironments of the endometrium and show that downregulation of WNT or NOTCH pathways increases the differentiation efficiency along the secretory and ciliated lineages, respectively.