Stefano Piotto

TL;DR: The role of microdomains in relation to various human pathologies such as cardiovascular disease, cancer and neurodegenerative diseases, and the concept of modifying membrane lipids (lipid therapy) as a means for treating such pathologies is introduced.

TL;DR: This work presents an antimicrobial peptide database (YADAMP) based on an extensive literature search, focused primarily on bacteria, with detailed information for 2133 peptides active against bacteria.

TL;DR: The classic heat shock (stress) response (HSR) was originally attributed to protein denaturation, but it is observed that a deregulated HSR is found in a large number of important diseases where more detailed knowledge of the molecular mechanisms involved may offer timely opportunities for clinical interventions and new, innovative drug treatments.

TL;DR: In a human embryonic kidney cell line, it is demonstrated that BGP-15 is able to inhibit the rapid heat shock factor 1 acetylation monitored during the early phase of heat stress, thereby promoting a prolonged duration of HSF1 binding to heat shock elements.

TL;DR: The membrane (and lipid) interacting hydroximic acid (HA) derivatives discussed in this review physiologically restore the heat shock protein stress response, creating a new class of "membrane-lipid therapy" pharmaceuticals.