Stéphane Laurent

TL;DR: A dose-dependent and blood pressure–independent reduction in carotid stiffness under chronic treatment with an angiotensin-converting enzyme inhibitor is indicated, suggesting that arterial distensibility was increased through an inward remodeling, leading to a reduction in wall stress, thus reducing elastic modulus.

TL;DR: Treatment consists in the opposition to the underlying mechanisms of the metabolic syndrome, adopting lifestyle interventions that effectively reduce visceral obesity with or without the use of drugs that oppose the development of insulin resistance or body weight gain.

TL;DR: The present review discusses the complexity of factors linking large artery to microvascular brain disease and to cognitive decline and the evidence for possible clinical markers useful for prevention of this phenomenon and the possibility of dementia prevention by cardiovascular risk factors control.

TL;DR: Two promising therapeutic alternatives for patients with resistant hypertension are discussed: novel drugs, including new pharmacological classes and new molecules from present pharmacological Classes with additional properties in blood-pressure or metabolism pathways; and new procedures and devices, including stimulation of arterial baroreceptors and catheter-based renal denervation.

TL;DR: It is concluded that maladaptive remodeling of the carotid artery and increased pulse pressure independently associate with faster decline of renal function and progression to ESRD.