S
Stephen D. Bell
Researcher at Indiana University
Publications - 121
Citations - 8315
Stephen D. Bell is an academic researcher from Indiana University. The author has contributed to research in topics: DNA replication & Origin recognition complex. The author has an hindex of 54, co-authored 117 publications receiving 7874 citations. Previous affiliations of Stephen D. Bell include University of Oxford & Anderson University (Indiana).
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Journal ArticleDOI
A Role for the ESCRT System in Cell Division in Archaea
TL;DR: It is found that Sulfolobus ESCRT-III and Vps4 homologs underwent regulation of their expression during the cell cycle, and these proteins specifically localized to the mid-cell during cell division.
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The Interaction of Alba, a Conserved Archaeal Chromatin Protein, with Sir2 and Its Regulation by Acetylation
Stephen D. Bell,Catherine H. Botting,Benjamin N. Wardleworth,Stephen P. Jackson,Malcolm F. White +4 more
TL;DR: Sir2 can deacetylate Alba and mediate transcriptional repression in a reconstituted in vitro transcription system, providing a paradigm for how Sir2 family proteins influence transcription and suggesting that modulation of chromatin structure by acetylation arose before the divergence of the archaeal and eukaryotic lineages.
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Identification of Two Origins of Replication in the Single Chromosome of the Archaeon Sulfolobus solfataricus
Nicholas P. Robinson,Isabelle Dionne,Magnus Lundgren,Victoria L. Marsh,Rolf Bernander,Stephen D. Bell +5 more
TL;DR: This work describes the identification of two active origins of replication in the single chromosome of the hyperthermophilic archaeon Sulfolobus solfataricus and identifies conserved sequence motifs within the origins that are recognized by a family of three Sulfoobus proteins that are homologous to the eukaryotic initiator proteins Orc1 and Cdc6.
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DNA Replication in the Archaea
TL;DR: A number of structures have now been obtained for individual components and higher-order assemblies of archaeal replication factors, yielding important insights into the mechanisms of DNA replication in both archaea and eukaryotes.
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A heterotrimeric PCNA in the hyperthermophilic archaeon Sulfolobus solfataricus.
TL;DR: Unique subunit-specific interactions between components of the clamp loader, RFC, suggest a model for clamp loading of PCNA, and provides a mechanism to tightly couple DNA synthesis and Okazaki fragment maturation.