A Role for the ESCRT System in Cell Division in Archaea
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TLDR
It is found that Sulfolobus ESCRT-III and Vps4 homologs underwent regulation of their expression during the cell cycle, and these proteins specifically localized to the mid-cell during cell division.Abstract:
Archaea are prokaryotic organisms that lack endomembrane structures. However, a number of hyperthermophilic members of the Kingdom Crenarchaea, including members of the Sulfolobus genus, encode homologs of the eukaryotic endosomal sorting system components Vps4 and ESCRT-III (endosomal sorting complex required for transport–III). We found that Sulfolobus ESCRT-III and Vps4 homologs underwent regulation of their expression during the cell cycle. The proteins interacted and we established the structural basis of this interaction. Furthermore, these proteins specifically localized to the mid-cell during cell division. Overexpression of a catalytically inactive mutant Vps4 in Sulfolobus resulted in the accumulation of enlarged cells, indicative of failed cell division. Thus, the archaeal ESCRT system plays a key role in cell division.read more
Citations
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
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The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
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Nitrosopumilus maritimus genome reveals unique mechanisms for nitrification and autotrophy in globally distributed marine crenarchaea
Christopher B. Walker,J.R. de la Torre,Martin G. Klotz,Hidetoshi Urakawa,Nicolás Pinel,Daniel J. Arp,Céline Brochier-Armanet,Patrick S. G. Chain,Patrick S. G. Chain,Patrick S. G. Chain,Patricia P. Chan,A. Gollabgir,James Hemp,Michael Hügler,Elizabeth A. Karr,Martin Könneke,Maria W. Shin,Maria W. Shin,Thomas J. Lawton,Todd M. Lowe,Willm Martens-Habbena,Luis A. Sayavedra-Soto,D. Lang,D. Lang,Stefan M. Sievert,Amy C. Rosenzweig,Gerard Manning,David A. Stahl +27 more
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Membrane budding and scission by the ESCRT machinery: it's all in the neck
TL;DR: The endosomal sorting complexes required for transport (ESCRTs) catalyse one of the most unusual membrane remodelling events in cell biology, which is crucial for many processes, including the biogenesis of multivesicular bodies, viral budding, cytokinesis and, probably, autophagy.
References
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Archaeal dominance in the mesopelagic zone of the Pacific Ocean
TL;DR: A year-long study of the abundance of two specific archaeal groups (pelagic euryarchaeota and pelagic crenarchAEota) in one of the ocean's largest habitats suggests that most pelagic deep-sea microorganisms are metabolically active and the results suggest that the global oceans harbour approximately 1.3 × 1028Archaeal cells, and 3.1×10 28 bacterial cells.
Journal ArticleDOI
The emerging shape of the ESCRT machinery
Roger L. Williams,Sylvie Urbé +1 more
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Parallels Between Cytokinesis and Retroviral Budding: A Role for the ESCRT Machinery
TL;DR: It is found that two proteins involved in HIV-1 budding—tumor susceptibility gene 101 (Tsg101), a subunit of the endosomal sorting complex required for transport I (ESCRT-I), and Alix, an ESCRT-associated protein—were recruited to the midbody during cytokinesis by interaction with centrosome protein 55 (Cep55), a centrosomesome and midbody protein essential for abscission.
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Biogenesis and Function of Multivesicular Bodies
TL;DR: The proper delivery of proteins to the MVB interior relies on specific ubiquitination of cargo, recognition and sorting of ubiquitinated cargo to endosomal subdomains, and the formation and scission of cargo-filled intralumenal vesicles.