S
Stephen Rea
Researcher at National University of Ireland, Galway
Publications - 13
Citations - 8069
Stephen Rea is an academic researcher from National University of Ireland, Galway. The author has contributed to research in topics: Histone methyltransferase & Histone H2A. The author has an hindex of 11, co-authored 13 publications receiving 7625 citations. Previous affiliations of Stephen Rea include Research Institute of Molecular Pathology & National University of Ireland.
Papers
More filters
Journal ArticleDOI
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
TL;DR: It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.
Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.
Journal ArticleDOI
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.
Stefan Kubicek,Roderick J. O'Sullivan,E. Michael August,Eugene R. Hickey,Qiang Zhang,Miguel L L. Teodoro,Stephen Rea,Karl Mechtler,Jennifer A. Kowalski,Carol Ann Homon,Terence A. Kelly,Thomas Jenuwein +11 more
TL;DR: In this article, the authors identify a biologically active HMTase inhibitor that allows for the transient modulation of H3K9me2 marks in mammalian chromatin and demonstrate that transient incubation of several cell lines with BIX-01294 lowers bulk H3 K 9me2 levels that are restored upon removal of the inhibitor.
Journal ArticleDOI
Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing.
Gunnar Schotta,Anja Ebert,Veiko Krauss,Andreas Fischer,Jan Hoffmann,Stephen Rea,Thomas Jenuwein,Rainer Dorn,Gunter Reuter +8 more
TL;DR: A central role for the SU(VAR)3–9 HMTase in heterochromatin‐induced gene silencing in Drosophila is indicated and the human SUV39H1 gene is able to partially rescue Su(var)3-9 silencing defects.
Journal ArticleDOI
Isolation and Characterization of Suv39h2, a Second Histone H3 Methyltransferase Gene That Displays Testis-Specific Expression
Dónal O'Carroll,Harry Scherthan,Antoine H.F.M. Peters,Susanne Opravil,Andrew R. Haynes,Götz Laible,Stephen Rea,Manfred Schmid,Angelika Lebersorger,Martin Jerratsch,Lydia Sattler,Marie Geneviève Mattei,Paul Denny,Stephen D.M. Brown,Dieter Schweizer,Thomas Jenuwein +15 more
TL;DR: Immunolocalization of Suv39h2 protein during spermatogenesis indicates enriched distribution at the heterochromatin from the leptotene to the round sperMatid stage, suggesting an additional function of the Suv 39h2 HMTase in organizing meiotic heterochromeatin that may even impart an epigenetic imprint to the male germ line.