N
Nanette C. Schloot
Researcher at University of Düsseldorf
Publications - 149
Citations - 4803
Nanette C. Schloot is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Type 1 diabetes & Diabetes mellitus. The author has an hindex of 37, co-authored 137 publications receiving 4249 citations. Previous affiliations of Nanette C. Schloot include Anschutz Medical Campus & Eli Lilly and Company.
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Journal ArticleDOI
Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice.
TL;DR: Six independently derived insulin‐specific T cell clones established from islet infiltrates of pre‐diabetic NOD mice were found to be specific to a region of the insulin molecule defined by a synthetic peptide encompassing residues 9–23 of the B chain.
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Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials.
Antoinette Moran,Brian N. Bundy,Dorothy J. Becker,Linda A. DiMeglio,Stephen E. Gitelman,Robin Goland,Carla J. Greenbaum,Kevan C. Herold,Jennifer B. Marks,Philip Raskin,Srinath Sanda,Desmond A. Schatz,Diane K. Wherrett,Darrell M. Wilson,Jeffrey P. Krischer,Jay S. Skyler,Linda Pickersgill,Eelco J.P. de Koning,Anette-G. Ziegler,Bernhard O. Boehm,Klaus Badenhoop,Nanette C. Schloot,Jens Friis Bak,Paolo Pozzilli,Didac Mauricio,Marc Y. Donath,Luis Castaño,Ana M. Wägner,H.H. Lervang,Hans Perrild,Thomas Mandrup-Poulsen +30 more
TL;DR: Canakinumab and anakinra were safe but were not effective as single immunomodulatory drugs in recent-onset type 1 diabetes and interleukin-1 blockade might be more effective in combination with treatments that target adaptive immunity in organ-specific autoimmune disorders.
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Adult-Onset Autoimmune Diabetes in Europe Is Prevalent With a Broad Clinical Phenotype: Action LADA 7
Mohammed I. Hawa,Hubert Kolb,Nanette C. Schloot,Huriya Beyan,Stavroula A Paschou,Raffaella Buzzetti,Didac Mauricio,Alberto de Leiva,Knud Bonnet Yderstræde,Henning Beck-Neilsen,Jaakko Tuomilehto,Cinzia Sarti,Charles Thivolet,David R. Hadden,Steven J. Hunter,Guntram Schernthaner,Werner A. Scherbaum,Rhys Williams,Sinead Brophy,Paolo Pozzilli,Paolo Pozzilli,Richard David Leslie +21 more
TL;DR: The results indicate that adult-onset autoimmune diabetes in Europe encompasses type 1 diabetes and LADA in the same broad clinical and autoantibody-positive spectrum.
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Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society
Roberto Mallone,Stuart I. Mannering,Barbara Brooks-Worrell,Ivana Durinovic-Belló,Corrado M. Cilio,Florence Susan Wong,Nanette C. Schloot +6 more
TL;DR: Recommendations on processing blood samples for T cell assays are proposed and gaps in knowledge are identified, relevant not only for the analysis of T cell responses in autoimmune disease, but also in cancer and infectious disease, particularly in the context of clinical trials.
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Elevated levels of the anti-inflammatory interleukin-1 receptor antagonist precede the onset of type 2 diabetes: the Whitehall II study.
Christian Herder,Eric J. Brunner,Wolfgang Rathmann,Klaus Strassburger,Adam G. Tabak,Nanette C. Schloot,Daniel R. Witte +6 more
TL;DR: The findings indicate that individuals who will develop type 2 diabetes are characterized by a complex immune activation that also includes upregulation of the anti-inflammatory cytokine IL-1Ra.