Sujatha Narayanan

TL;DR: It is demonstrated that the global population structure of M. tuberculosis is defined by six phylogeographical lineages, each associated with specific, sympatric human populations, and in an urban cosmopolitan environment, mycobacterial lineages were much more likely to spread in sympatrics than in allopatric patient populations.

TL;DR: Molecular diagnostics that include markers for rifampicin resistance alone will be insufficient to identify pre-MDR strains, and incorporation of knowledge of polymorphisms that occur before the emergence of multidrug resistance, particularly katG p.Ser315Thr, into molecular diagnostics should enable targeted treatment of patients with pre-mDR-TB to prevent further development of MDR- TB.

TL;DR: Three novel mutations and three new alleles within and outside the RRDR, along with two novel mutations outside theRRDR, are reported in this study.

TL;DR: Molecular epidemiologic findings suggest an ancient focus of TB, and suggest it may be related to infectious disease-related coronavirus-related infections such as pneumonia and tuberculosis.

TL;DR: Evidence is provided that the functional serine/threonine kinase, PknE, is important for survival of M. tuberculosis that enhances macrophage viability by inhibiting apoptosis, and a novel mechanism, by which PKnE senses nitric oxide stress and prevents apoptosis by interfering with host signalling pathways is suggested.