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Sinéad B. Chapman

Researcher at Broad Institute

Publications -  32
Citations -  5207

Sinéad B. Chapman is an academic researcher from Broad Institute. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 15, co-authored 24 publications receiving 4065 citations. Previous affiliations of Sinéad B. Chapman include Massachusetts Institute of Technology.

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Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium

Li-Jun Ma, +65 more
- 18 Mar 2010 - 
TL;DR: Comparison of genomes of three phenotypically diverse Fusarium species revealed lineage-specific genomic regions in F. oxysporum that include four entire chromosomes and account for more than one-quarter of the genome, putting the evolution of fungal pathogenicity into a new perspective.
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Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak

TL;DR: This West African variant likely diverged from central African lineages around 2004, crossed from Guinea to Sierra Leone in May 2014, and has exhibited sustained human-to-human transmission subsequently, with no evidence of additional zoonotic sources.
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Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics

Peter Arensburger, +81 more
- 01 Oct 2010 - 
TL;DR: The genomic sequence of C. quinquefasciatus is described, which reveals distinctions related to vector capacities and habitat preferences, and confirmed that inoculation with unfamiliar bacteria prompted strong immune responses in Culex.
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Ebola virus epidemiology, transmission, and evolution during seven months in Sierra Leone

Daniel J. Park, +96 more
- 18 Jun 2015 - 
TL;DR: Analysis of sequences from 232 patients sampled over 7 months in Sierra Leone, along with 86 previously released genomes from earlier in the epidemic, confirms sustained human-to-human transmission within Sierra Leone and finds no evidence for import or export of EBOV across national borders after its initial introduction.
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Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events.

TL;DR: Investigating the introduction and spread of severe acute respiratory syndrome coronavirus 2 in the Boston area across the first wave of the pandemic provides powerful evidence of the importance of superspreading events in shaping the course of this pandemic and illustrates how some introductions, when amplified under unfortunate circumstances, can have an outsized effect with devastating consequences that extend far beyond the initial events themselves.