S
Sinéad B. Chapman
Researcher at Broad Institute
Publications - 32
Citations - 5207
Sinéad B. Chapman is an academic researcher from Broad Institute. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 15, co-authored 24 publications receiving 4065 citations. Previous affiliations of Sinéad B. Chapman include Massachusetts Institute of Technology.
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Journal ArticleDOI
Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium
Li-Jun Ma,H. Charlotte van der Does,Katherine A. Borkovich,Jeffrey J. Coleman,Marie Josée Daboussi,Antonio Di Pietro,Marie Dufresne,Michael Freitag,Manfred Grabherr,Bernard Henrissat,Petra M. Houterman,Seogchan Kang,Won-Bo Shim,Charles P. Woloshuk,Xiaohui Xie,Jin-Rong Xu,John F. Antoniw,Scott E. Baker,B. H. Bluhm,Andrew Breakspear,Daren W. Brown,Robert A. E. Butchko,Sinéad B. Chapman,Richard M.R. Coulson,Pedro M. Coutinho,Etienne Danchin,Etienne Danchin,Andrew C. Diener,Liane R. Gale,Donald M. Gardiner,Stephen A. Goff,Kim E. Hammond-Kosack,Karen Hilburn,Aurélie Hua-Van,Wilfried Jonkers,Kemal Kazan,Chinnappa D. Kodira,Michael Koehrsen,Lokesh Kumar,Yong-Hwan Lee,Liande Li,Liande Li,John M. Manners,Diego Miranda-Saavedra,Mala Mukherjee,Gyungsoon Park,Jongsun Park,Sook Young Park,Sook Young Park,Robert H. Proctor,Aviv Regev,M. Carmen Ruiz-Roldán,Divya Sain,Sharadha Sakthikumar,Sean M. Sykes,David C. Schwartz,B. Gillian Turgeon,Ilan Wapinski,Olen C. Yoder,Sarah Young,Qiandong Zeng,Shiguo Zhou,James E. Galagan,Christina A. Cuomo,H. Corby Kistler,Martijn Rep +65 more
TL;DR: Comparison of genomes of three phenotypically diverse Fusarium species revealed lineage-specific genomic regions in F. oxysporum that include four entire chromosomes and account for more than one-quarter of the genome, putting the evolution of fungal pathogenicity into a new perspective.
Journal ArticleDOI
Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak
Stephen K. Gire,Stephen K. Gire,Augustine Goba,Kristian G. Andersen,Kristian G. Andersen,Rachel Sealfon,Rachel Sealfon,Daniel J. Park,Lansana Kanneh,Simbirie Jalloh,Mambu Momoh,Mohamed Fullah,Gytis Dudas,Shirlee Wohl,Shirlee Wohl,Lina M. Moses,Nathan L. Yozwiak,Nathan L. Yozwiak,Sarah M. Winnicki,Sarah M. Winnicki,Christian B. Matranga,Christine M. Malboeuf,James Qu,Adrianne Gladden,Stephen F. Schaffner,Stephen F. Schaffner,Xiao Yang,Pan Pan Jiang,Pan Pan Jiang,Mahan Nekoui,Mahan Nekoui,Andrés Colubri,Moinya Ruth Coomber,Mbalu Fonnie,Alex Moigboi,Michael Gbakie,Fatima K. Kamara,Veronica Tucker,Edwin Konuwa,Sidiki Saffa,Josephine Sellu,Abdul A. Jalloh,Alice Kovoma,James Koninga,Ibrahim Mustapha,Kandeh Kargbo,Momoh Foday,Mohamed Yillah,Franklyn Kanneh,Willie Robert,James L.B. Massally,Sinéad B. Chapman,James Bochicchio,Cheryl I. Murphy,Chad Nusbaum,Sarah Young,Bruce W. Birren,Donald S. Grant,John S. Scheiffelin,Eric S. Lander,Eric S. Lander,Eric S. Lander,Christian T. Happi,Sahr M. Gevao,Andreas Gnirke,Andrew Rambaut,Andrew Rambaut,Robert F. Garry,S. Humarr Khan,Pardis C. Sabeti,Pardis C. Sabeti +70 more
TL;DR: This West African variant likely diverged from central African lineages around 2004, crossed from Guinea to Sierra Leone in May 2014, and has exhibited sustained human-to-human transmission subsequently, with no evidence of additional zoonotic sources.
Journal ArticleDOI
Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics
Peter Arensburger,Karyn Megy,Robert M. Waterhouse,Robert M. Waterhouse,Jenica L. Abrudan,Paolo Amedeo,Beatriz García Antelo,Lyric C. Bartholomay,Shelby L. Bidwell,Elisabet Caler,Francisco Camara,Corey L. Campbell,Kathryn S. Campbell,Claudio Casola,Marta T Castro,Ishwar Chandramouliswaran,Sinéad B. Chapman,Scott Christley,Javier Costas,Eric Eisenstadt,Cédric Feschotte,Claire M. Fraser-Liggett,Roderic Guigó,Brian J. Haas,Martin Hammond,Bill S. Hansson,Janet Hemingway,Sharon R. Hill,Clint Howarth,Rickard Ignell,Ryan C. Kennedy,Chinnappa D. Kodira,Neil F. Lobo,Chunhong Mao,George F. Mayhew,Kristin Michel,Akio Mori,Nannan Liu,Horacio Naveira,Vishvanath Nene,Vishvanath Nene,Nam P. Nguyen,Matthew D. Pearson,Ellen J. Pritham,Daniela Puiu,Yumin Qi,Hilary Ranson,José M. C. Ribeiro,Hugh M Roberston,David W. Severson,Martin Shumway,Mario Stanke,Robert L. Strausberg,Cheng Sun,Granger G. Sutton,Zhijian Jake Tu,Jose M. C. Tubio,Maria F. Unger,Dana L. Vanlandingham,Albert J. Vilella,Owen White,Jared White,Charles S. Wondji,Jennifer R. Wortman,Evgeny M. Zdobnov,Evgeny M. Zdobnov,Evgeny M. Zdobnov,Bruce W. Birren,Bruce M. Christensen,Frank H. Collins,Anthony J. Cornel,George Dimopoulos,Linda Hannick,Stephen Higgs,Gregory C. Lanzaro,Daniel Lawson,Norman H. Lee,Marc A. T. Muskavitch,Marc A. T. Muskavitch,Marc A. T. Muskavitch,Alexander S. Raikhel,Peter W. Atkinson +81 more
TL;DR: The genomic sequence of C. quinquefasciatus is described, which reveals distinctions related to vector capacities and habitat preferences, and confirmed that inoculation with unfamiliar bacteria prompted strong immune responses in Culex.
Journal ArticleDOI
Ebola virus epidemiology, transmission, and evolution during seven months in Sierra Leone
Daniel J. Park,Gytis Dudas,Shirlee Wohl,Shirlee Wohl,Augustine Goba,Shannon L.M. Whitmer,Kristian G. Andersen,Rachel Sealfon,Rachel Sealfon,Jason T. Ladner,Jeffrey R. Kugelman,Christian B. Matranga,Sarah M. Winnicki,Sarah M. Winnicki,James Qu,Stephen K. Gire,Stephen K. Gire,Adrianne Gladden-Young,Simbirie Jalloh,Dolo Nosamiefan,Nathan L. Yozwiak,Nathan L. Yozwiak,Lina M. Moses,Pan Pan Jiang,Pan Pan Jiang,Aaron E. Lin,Aaron E. Lin,Stephen F. Schaffner,Stephen F. Schaffner,Brian H. Bird,Jonathan S. Towner,Mambu Mamoh,Michael Gbakie,Lansana Kanneh,David Kargbo,James L.B. Massally,Fatima K. Kamara,Edwin Konuwa,Josephine Sellu,Abdul A. Jalloh,Ibrahim Mustapha,Momoh Foday,Mohamed Yillah,Bobbie R. Erickson,Tara K. Sealy,Dianna M. Blau,Christopher D. Paddock,Aaron C. Brault,Brian R. Amman,Jane Basile,Scott W. Bearden,Jessica A. Belser,Eric Bergeron,Shelley Campbell,Ayan K. Chakrabarti,Kimberly A. Dodd,Mike Flint,Aridth Gibbons,Christin H. Goodman,John D. Klena,Laura K. Mcmullan,Laura Morgan,Brandy J. Russell,Johanna S. Salzer,Angela J. Sanchez,David Wang,Irwin Jungreis,Christopher Tomkins-Tinch,Andrey Kislyuk,Michael F. Lin,Sinéad B. Chapman,Bronwyn MacInnis,Ashley Matthews,Ashley Matthews,James Bochicchio,Lisa E. Hensley,Jens H. Kuhn,Chad Nusbaum,John S. Schieffelin,Bruce W. Birren,Marc Forget,Stuart T. Nichol,Gustavo Palacios,Daouda Ndiaye,Christian T. Happi,Sahr M. Gevao,Mohamed A. Vandi,Brima Kargbo,Edward C. Holmes,Trevor Bedford,Andreas Gnirke,Ute Ströher,Andrew Rambaut,Andrew Rambaut,Robert F. Garry,Pardis C. Sabeti,Pardis C. Sabeti +96 more
TL;DR: Analysis of sequences from 232 patients sampled over 7 months in Sierra Leone, along with 86 previously released genomes from earlier in the epidemic, confirms sustained human-to-human transmission within Sierra Leone and finds no evidence for import or export of EBOV across national borders after its initial introduction.
Journal ArticleDOI
Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events.
Jacob E. Lemieux,Jacob E. Lemieux,Katherine J. Siddle,Katherine J. Siddle,Bennett M. Shaw,Bennett M. Shaw,Christine Loreth,Stephen F. Schaffner,Stephen F. Schaffner,Adrianne Gladden-Young,Gordon Adams,Timelia Fink,Christopher Tomkins-Tinch,Christopher Tomkins-Tinch,Lydia A. Krasilnikova,Lydia A. Krasilnikova,Katherine C. DeRuff,Melissa Rudy,Matthew R. Bauer,Matthew R. Bauer,Kim A. Lagerborg,Kim A. Lagerborg,Erica Normandin,Erica Normandin,Sinéad B. Chapman,Steven K. Reilly,Steven K. Reilly,Melis N. Anahtar,Aaron E. Lin,Aaron E. Lin,Amber Carter,Cameron Myhrvold,Cameron Myhrvold,Molly Kemball,Molly Kemball,Sushma Chaluvadi,Caroline N. Cusick,Katelyn Flowers,Anna Neumann,Felecia Cerrato,Maha R. Farhat,Damien Slater,Jason B. Harris,John A. Branda,David C. Hooper,Jessie M. Gaeta,Travis P. Baggett,James J. O’Connell,Andreas Gnirke,Tami D. Lieberman,Tami D. Lieberman,Anthony A. Philippakis,Meagan Burns,Catherine M. Brown,Jeremy Luban,Jeremy Luban,Edward T. Ryan,Sarah E Turbett,Regina C. LaRocque,William P. Hanage,Glen R. Gallagher,Lawrence C. Madoff,Lawrence C. Madoff,Sandra Smole,Virginia M. Pierce,Eric S. Rosenberg,Pardis C. Sabeti,Daniel J. Park,Bronwyn MacInnis,Bronwyn MacInnis +69 more
TL;DR: Investigating the introduction and spread of severe acute respiratory syndrome coronavirus 2 in the Boston area across the first wave of the pandemic provides powerful evidence of the importance of superspreading events in shaping the course of this pandemic and illustrates how some introductions, when amplified under unfortunate circumstances, can have an outsized effect with devastating consequences that extend far beyond the initial events themselves.