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Ahmed Elewa
Researcher at Karolinska Institutet
Publications - 25
Citations - 2321
Ahmed Elewa is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 9, co-authored 15 publications receiving 2177 citations. Previous affiliations of Ahmed Elewa include Harvard University & University of Massachusetts Medical School.
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Journal ArticleDOI
A Map of the Interactome Network of the Metazoan C. elegans
Siming Li,Christopher M. Armstrong,Nicolas Bertin,Hui Ge,Stuart Milstein,Mike Boxem,Pierre-Olivier Vidalain,Jing-Dong J. Han,Alban Chesneau,Tong Hao,Debra S. Goldberg,Ning Li,Monica Martinez,Jean François Rual,Philippe Lamesch,Lai Xu,Lai Xu,Muneesh Tewari,Sharyl L. Wong,Lan V. Zhang,Gabriel F. Berriz,Laurent Jacotot,Philippe Vaglio,Jérôme Reboul,Tomoko Hirozane-Kishikawa,Qian-Ru Li,Harrison W. Gabel,Ahmed Elewa,Ahmed Elewa,Bridget L. Baumgartner,Debra J. Rose,Haiyuan Yu,Stephanie Bosak,Reynaldo Sequerra,Andrew G. Fraser,Susan E. Mango,William M. Saxton,Susan Strome,Sander van den Heuvel,Fabio Piano,Jean Vandenhaute,Claude Sardet,Mark Gerstein,Lynn Doucette-Stamm,Kristin C. Gunsalus,J. Wade Harper,J. Wade Harper,Michael E. Cusick,Frederick P. Roth,David E. Hill,Marc Vidal +50 more
TL;DR: A large fraction of the Caenorhabditis elegans interactome network is mapped, starting with a subset of metazoan-specific proteins, and more than 4000 interactions were identified from high-throughput, yeast two-hybrid screens.
Journal ArticleDOI
A gene-centered C. elegans protein-DNA interaction network
Bart Deplancke,Arnab Mukhopadhyay,Wanyuan Ao,Ahmed Elewa,Christian A. Grove,Natalia J. Martinez,Reynaldo Sequerra,Lynn Doucette-Stamm,John S. Reece-Hoyes,Ian A. Hope,Heidi A. Tissenbaum,Susan E. Mango,Albertha J.M. Walhout +12 more
TL;DR: This work uses "gene-centered" high-throughput yeast one-hybrid (Y1H) assays to identify 283 interactions between 72 C. elegans digestive tract gene promoters and 117 proteins, and provides functional annotations for approximately 10% of all worm TFs and finds ten novel putative TFs, illustrating the power of a gene-centered approach.
Journal ArticleDOI
Reading and editing the Pleurodeles waltl genome reveals novel features of tetrapod regeneration.
Ahmed Elewa,Heng Wang,Carlos Talavera-López,Carlos Talavera-López,Alberto Joven,Goncalo Brito,Anoop Kumar,L. Shahul Hameed,May Penrad-Mobayed,Zeyu Yao,Neda Zamani,Yamen Abbas,Ilgar Abdullayev,Ilgar Abdullayev,Rickard Sandberg,Rickard Sandberg,Manfred Grabherr,Björn Andersson,András Simon +18 more
TL;DR: The Iberian ribbed newt Pleurodeles waltl has a wide spectrum of regeneration abilities and its ~20 Gb genome and transcriptome are sequence to investigate the molecular features underlying its regenerative capacities.
Journal ArticleDOI
Model systems for regeneration: salamanders
TL;DR: The evolutionary context in which salamanders emerged is covered, and the varieties of mechanisms deployed during salamander regeneration are outlined, and how these mechanisms are currently being explored and how they have advanced the understanding of animal regeneration.
Journal ArticleDOI
Fgf-signaling is compartmentalized within the mesenchyme and controls proliferation during salamander limb development.
TL;DR: Investigation of how Sonic hedgehog and Fibroblast growth factor signaling regulate limb development in the axolotl found that Shh-expressing cells contributed to the most posterior digit, and that inhibiting ShH-signaling inhibited Fgf8 expression, anteroposterior patterning, and distal cell proliferation.