S
Susan M. Domchek
Researcher at University of Pennsylvania
Publications - 501
Citations - 37655
Susan M. Domchek is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 83, co-authored 439 publications receiving 30495 citations. Previous affiliations of Susan M. Domchek include Brigham and Women's Hospital & Cancer Council Victoria.
Papers
More filters
Journal ArticleDOI
Contribution of Germline Predisposition Gene Mutations to Breast Cancer Risk in African American Women.
Julie R. Palmer,Eric C. Polley,Chunling Hu,Esther M. John,Christopher A. Haiman,Steven N. Hart,Mia M. Gaudet,Tuya Pal,Hoda Anton-Culver,Amy Trentham-Dietz,Leslie Bernstein,Christine B. Ambrosone,Elisa V. Bandera,Kimberly A. Bertrand,Traci N. Bethea,Chi Gao,Rohan Gnanaolivu,Hongyan Huang,Kun Y. Lee,Loic LeMarchand,Jie Na,Dale P. Sandler,Payal D. Shah,Siddhartha Yadav,William Yang,Jeffrey N. Weitzel,Susan M. Domchek,David E Goldgar,David E Goldgar,Katherine L. Nathanson,Peter Kraft,Song Yao,Fergus J. Couch +32 more
TL;DR: The study identifies genes that predispose to breast cancer in the AA population, demonstrates the validity of current breast cancer testing panels for use in AA women, and provides a basis for increased referral of AA patients for cancer genetic testing.
Journal ArticleDOI
Multiplex genetic testing: reconsidering utility and informed consent in the era of next-generation sequencing.
TL;DR: Multiplex genetic testing is reconsidering utility and informed consent in the era of next-generation sequencing.
Journal ArticleDOI
Use of total abdominal hysterectomy and hormone replacement therapy in BRCA1 and BRCA2 mutation carriers undergoing risk-reducing salpingo-oophorectomy.
C. A. Gabriel,J. Tigges-Cardwell,Jill Stopfer,Julie Erlichman,Katherine L. Nathanson,Susan M. Domchek +5 more
TL;DR: In this single institution study, the majority of BRCA1/2 mutation carriers undergoing RRSO also underwent TAH, and a substantial number took HRT, although this result did not reach statistical significance.
Journal ArticleDOI
Clinical management of BRCA1 and BRCA2 mutation carriers.
TL;DR: Current evidence for strategies to reduce the risks of cancer development in women with BRCA1/2mutations is outlined, and future research directions are discussed.
Journal ArticleDOI
Predicting BRCA1 and BRCA2 gene mutation carriers: comparison of PENN II model to previous study.
Noralane M. Lindor,Kiley J. Johnson,Hayden Harvey,V. Shane Pankratz,Susan M. Domchek,Katherine S. Hunt,Marcia Wilson,M. Cathie Smith,Fergus J. Couch +8 more
TL;DR: PENN II model for BRCA1/2 prediction performed well in this population with higher AUC compared with the experience using four other models, and the ease of use of the PENNII model is compatible with busy clinical practices.