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Susan M. Domchek

Susan M. Domchek

Researcher at University of Pennsylvania

Publications - 501

Citations - 37655

Susan M. Domchek is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 83, co-authored 439 publications receiving 30495 citations. Previous affiliations of Susan M. Domchek include Brigham and Women's Hospital & Cancer Council Victoria.

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Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Catherine M. Phelan,Karoline Kuchenbaecker,Karoline Kuchenbaecker,Jonathan Tyrer,Siddhartha Kar,Kate Lawrenson,Stacey J. Winham,Joe Dennis,Ailith Pirie,Marjorie J. Riggan,Ganna Chornokur,Madalene Earp,Paulo C Lyra,Janet M. Lee,Simon G. Coetzee,Jonathan Beesley,Lesley McGuffog,Penny Soucy,Ed Dicks,Andrew Lee,Daniel Barrowdale,Julie Lecarpentier,Goska Leslie,Cora M. Aalfs,Katja K.H. Aben,Marcia Adams,Julian Adlard,Irene L. Andrulis,Irene L. Andrulis,Hoda Anton-Culver,Natalia Antonenkova,Gerasimos Aravantinos,Norbert Arnold,Banu Arun,Brita Arver,Jacopo Azzollini,Judith Balmaña,Susana Banerjee,Laure Barjhoux,Rosa B. Barkardottir,Yukie Bean,Matthias W. Beckmann,Alicia Beeghly-Fadiel,Javier Benitez,Marina Bermisheva,Marcus Q. Bernardini,Michael J. Birrer,Line Bjørge,Line Bjørge,Amanda Black,Kenneth Blankstein,Marinus J. Blok,Clara Bodelon,Natalia Bogdanova,Anders Bojesen,Bernardo Bonanni,Åke Borg,Angela R. Bradbury,James D. Brenton,Carole Brewer,Louise A. Brinton,Per Broberg,Angela Brooks-Wilson,Fiona Bruinsma,Joan Brunet,Bruno Buecher,Ralf Bützow,Saundra S. Buys,Trinidad Caldés,Maria A. Caligo,Ian G. Campbell,Ian G. Campbell,Rikki Cannioto,Michael E. Carney,Terence Cescon,Salina B. Chan,Jenny Chang-Claude,Jenny Chang-Claude,Stephen J. Chanock,Xiaoqing Chen,Yoke-Eng Chiew,Yoke-Eng Chiew,Jocelyne Chiquette,Wendy K. Chung,Kathleen Claes,Thomas Conner,Linda S. Cook,Jackie Cook,Daniel W. Cramer,Julie M. Cunningham,Aimee A D'Aloisio,Mary B. Daly,Francesca Damiola,Sakaeva Dina Damirovna,Agnieszka Dansonka-Mieszkowska,Fanny Dao,Rosemarie Davidson,Anna deFazio,Anna deFazio,Capucine Delnatte,Kimberly F. Doheny,Orland Diez,Yuan Chun Ding,Jennifer A. Doherty,Susan M. Domchek,Cecilia M. Dorfling,Thilo Dörk,Laure Dossus,Mercedes Durán,Matthias Dürst,Bernd Dworniczak,Diana Eccles,Todd L. Edwards,Ros Eeles,Ursula Eilber,Bent Ejlertsen,Arif B. Ekici,Steve Ellis,Mingajeva Elvira,Kevin H. Eng,Christoph Engel,D. Gareth Evans,Peter A. Fasching,Peter A. Fasching,Sarah E. Ferguson,Sandra Fert Ferrer,James M. Flanagan,Zachary C. Fogarty,Renée T. Fortner,Florentia Fostira,William D. Foulkes,George Fountzilas,Brooke L. Fridley,Tara M. Friebel,Eitan Friedman,Eitan Friedman,Debra Frost,Patricia A. Ganz,Judy Garber,María Josefa Mosteiro García,Vanesa García-Barberán,Andrea Gehrig,Aleksandra Gentry-Maharaj,Anne-Marie Gerdes,Graham G. Giles,Graham G. Giles,Graham G. Giles,Rosalind Glasspool,Gord Glendon,Andrew K. Godwin,David E. Goldgar,Teodora Goranova,Martin Gore,Mark H. Greene,Jacek Gronwald,Stephen B. Gruber,Eric Hahnen,Christopher A. Haiman,Niclas Håkansson,Ute Hamann,Thomas Hansen,Patricia Harrington,Holly R. Harris,Jan Hauke,Alexander Hein,Alex Henderson,Michelle A.T. Hildebrandt,Peter Hillemanns,Shirley Hodgson,Claus Høgdall,Estrid Høgdall,Frans B. L. Hogervorst,Helene Holland,Maartje J. Hooning,Karen Hosking,Ruea-Yea Huang,Peter J. Hulick,Jillian Hung,Jillian Hung,David J. Hunter,David G. Huntsman,Tomasz Huzarski,Evgeny N. Imyanitov,Claudine Isaacs,Edwin S. Iversen,Louise Izatt,Angel Izquierdo,Anna Jakubowska,Paul A. James,Paul A. James,Ramunas Janavicius,Mats Jernetz,Allan Jensen,Uffe Birk Jensen,Esther M. John,Sharon E. Johnatty,Michael Jones,Päivi Kannisto,Beth Y. Karlan,Anthony N. Karnezis,Karin Kast,Catherine J. Kennedy,Catherine J. Kennedy,Elza Khusnutdinova,Lambertus A. Kiemeney,Johanna I. Kiiski,Sung-Won Kim,Susanne K. Kjaer,Martin Köbel,Reidun K. Kopperud,Reidun K. Kopperud,Torben A Kruse,Jolanta Kupryjanczyk,Ava Kwong,Yael Laitman,Yael Laitman,Diether Lambrechts,Nerea Larrañaga,Melissa C. Larson,Conxi Lázaro,Nhu D. Le,Loic Le Marchand,Jong Won Lee,Shashikant Lele,Arto Leminen,Dominique Leroux,Jenny Lester,Fabienne Lesueur,Fabienne Lesueur,Douglas A. Levine,Dong Liang,Clemens Liebrich,Jenna Lilyquist,Loren Lipworth,Jolanta Lissowska,Karen H. Lu,Jan Lubinński,Craig Luccarini,Lene Lundvall,Phuong L. Mai,Gustavo Mendoza-Fandiño,Siranoush Manoukian,Leon F.A.G. Massuger,Taymaa May,Sylvie Mazoyer,Jessica N. McAlpine,Valerie McGuire,John R. McLaughlin,Iain A. McNeish,Hanne Meijers-Heijboer,Alfons Meindl,Usha Menon,Arjen R. Mensenkamp,Melissa A. Merritt,Roger L. Milne,Roger L. Milne,Gillian Mitchell,Gillian Mitchell,Francesmary Modugno,Joanna Moes-Sosnowska,Melissa Moffitt,Marco Montagna,Kirsten B. Moysich,Anna Marie Mulligan,Anna Marie Mulligan,Jacob Musinsky,Katherine L. Nathanson,Lotte Nedergaard,Roberta B. Ness,Susan L. Neuhausen,Heli Nevanlinna,Dieter Niederacher,Robert L. Nussbaum,Kunle Odunsi,Edith Olah,Olufunmilayo I. Olopade,Håkan Olsson,Curtis Olswold,David M. O'Malley,Kai-ren Ong,N. Charlotte Onland-Moret,Nick Orr,Sandra Orsulic,Ana Osorio,Domenico Palli,Laura Papi,Tjoung-Won Park-Simon,James Paul,Celeste Leigh Pearce,Celeste Leigh Pearce,Inge Søkilde Pedersen,Petra H.M. Peeters,Bernard Peissel,Ana Peixoto,Tanja Pejovic,Liisa M. Pelttari,Jennifer B. Permuth,Paolo Peterlongo,Lidia Pezzani,Georg Pfeiler,Kelly-Anne Phillips,Kelly-Anne Phillips,Marion Piedmonte,Malcolm C. Pike,Malcolm C. Pike,Anna M. Piskorz,Samantha Poblete,Timea Pocza,Elizabeth M. Poole,Bruce Poppe,Mary Porteous,Fabienne Prieur,Darya Prokofyeva,Elizabeth W. Pugh,Miquel Angel Pujana,Pascal Pujol,Paolo Radice,Johanna Rantala,Christine Rappaport-Fuerhauser,Gad Rennert,Kerstin Rhiem,Patricia Rice,Andrea L. Richardson,Mark E. Robson,Gustavo C. Rodriguez,Cristina Rodríguez-Antona,Jane Romm,Matti A. Rookus,Mary Anne Rossing,Joseph H. Rothstein,Anja Rudolph,Ingo B. Runnebaum,Helga B. Salvesen,Helga B. Salvesen,Dale P. Sandler,Minouk J. Schoemaker,Leigha Senter,V. Wendy Setiawan,Gianluca Severi,Priyanka Sharma,Tameka Shelford,Nadeem Siddiqui,Lucy Side,Weiva Sieh,Christian F. Singer,Hagay Sobol,Honglin Song,Melissa C. Southey,Amanda B. Spurdle,Zsofia K. Stadler,Doris Steinemann,Dominique Stoppa-Lyonnet,Lara E. Sucheston-Campbell,Grzegorz Sukiennicki,Rebecca Sutphen,Christian Sutter,Anthony J. Swerdlow,Anthony J. Swerdlow,Csilla Szabo,Lukasz Szafron,Yen Y. Tan,Jack A. Taylor,Muy-Kheng Tea,Manuel R. Teixeira,Soo Hwang Teo,Kathryn L. Terry,Kathryn L. Terry,Pamela J. Thompson,Liv Cecilie Vestrheim Thomsen,Liv Cecilie Vestrheim Thomsen,Darcy L. Thull,Laima Tihomirova,Anna V. Tinker,Marc Tischkowitz,Silvia Tognazzo,Amanda E. Toland,Alicia A. Tone,Britton Trabert,Ruth C. Travis,Antonia Trichopoulou,Nadine Tung,Shelley S. Tworoger,Shelley S. Tworoger,Anne M. van Altena,David Van Den Berg,Annemarie H. van der Hout,Rob B. van der Luijt,Mattias Van Heetvelde,Els Van Nieuwenhuysen,Elizabeth J. van Rensburg,Adriaan Vanderstichele,Raymonda Varon-Mateeva,Ana Vega,Digna R. Velez Edwards,Digna R. Velez Edwards,Ignace Vergote,Robert A. Vierkant,Joseph Vijai,Athanassios Vratimos,Lisa Walker,Christine Walsh,Dorothea Wand,Shan Wang-Gohrke,Barbara Wappenschmidt,Penelope M. Webb,Clarice R. Weinberg,Jeffrey N. Weitzel,Nicolas Wentzensen,Alice S. Whittemore,Juul T. Wijnen,Lynne R. Wilkens,Alicja Wolk,Michelle M.M. Woo,Xifeng Wu,Anna H. Wu,Hannah P. Yang,Drakoulis Yannoukakos,Argyrios Ziogas,Kristin K. Zorn,Steven A. Narod,Douglas F. Easton,Christopher I. Amos,Joellen M. Schildkraut,Susan J. Ramus,Susan J. Ramus,Laura Ottini,Marc T. Goodman,Sue K. Park,Linda E. Kelemen,Harvey A. Risch,Mads Thomassen,Kenneth Offit,Jacques Simard,Rita K. Schmutzler,Dennis J. Hazelett,Alvaro N.A. Monteiro,Fergus J. Couch,Andrew Berchuck,Georgia Chenevix-Trench,Ellen L. Goode,Thomas A. Sellers,Simon A. Gayther,Antonis C. Antoniou,Paul D.P. Pharoah +443 moreUniversity of Cambridge,Wellcome Trust Sanger Institute,Cedars-Sinai Medical Center,Mayo Clinic,Duke University,QIMR Berghofer Medical Research Institute,Laval University,Radboud University Nijmegen,Johns Hopkins University School of Medicine,Chapel Allerton Hospital,University of Toronto,Lunenfeld-Tanenbaum Research Institute,University of California, Irvine,University of Kiel,University of Texas MD Anderson Cancer Center,Karolinska University Hospital,Hebron University,The Royal Marsden NHS Foundation Trust,University of Iceland,Oregon Health & Science University,University of Erlangen-Nuremberg,Russian Academy of Sciences,University Health Network,Harvard University,Haukeland University Hospital,University of Bergen,City of Hope National Medical Center,Maastricht University,Hannover Medical School,Lund University,University of Pennsylvania,Royal Devon and Exeter Hospital,BC Cancer Agency,Cancer Council Victoria,Curie Institute,University of Helsinki,Huntsman Cancer Institute,Hospital Clínico San Carlos,University of Pisa,University of Melbourne,Peter MacCallum Cancer Centre,Roswell Park Cancer Institute,University of Hawaii at Manoa,University of California, San Francisco,German Cancer Research Center,University of Hamburg,Westmead Hospital,University of Sydney,Columbia University,Ghent University,University of New Mexico,Boston Children's Hospital,Brigham and Women's Hospital,Durham University,Fox Chase Cancer Center,Bashkir State University,Memorial Sloan Kettering Cancer Center,University of Glasgow,Beckman Research Institute,Dartmouth College,University of Pretoria,International Agency for Research on Cancer,University of Valladolid,University of Jena,University of Southampton,Copenhagen University Hospital,Leipzig University,Central Manchester University Hospitals NHS Foundation Trust,University of California, Los Angeles,Imperial College London,McGill University,Aristotle University of Thessaloniki,University of Kansas,Tel Aviv University,Sheba Medical Center,University College London,Monash University,Beatson West of Scotland Cancer Centre,Mount Sinai Hospital, Toronto,University of Utah,National Institutes of Health,Pomeranian Medical University,University of Southern California,Karolinska Institutet,Centre for Life,St George's, University of London,University of Copenhagen,Netherlands Cancer Institute,Erasmus University Medical Center,University of Chicago,University of British Columbia,University of Washington,Guy's and St Thomas' NHS Foundation Trust,Vilnius University,Aarhus University Hospital,Cancer Prevention Institute of California,Institute of Cancer Research,Dresden University of Technology,Helsinki University Central Hospital,St Mary's Hospital,University of Calgary,Odense University Hospital,University of Hong Kong,Katholieke Universiteit Leuven,University of Hawaii,Asan Medical Center,Centre Hospitalier Universitaire de Grenoble,ParisTech,Texas Southern University,Vanderbilt University,University of Lyon,Vancouver General Hospital,Stanford University,VU University Amsterdam,Technische Universität München,University of Pittsburgh,St. Michael's Hospital,University of Texas at Austin,University of Düsseldorf,Ohio State University,Utrecht University,Breast Cancer Now,Prevention Institute,University of Florence,University of Michigan,Aalborg University,Medical University of Vienna,Western General Hospital,Rappaport Faculty of Medicine,NorthShore University HealthSystem,Fred Hutchinson Cancer Research Center,Glasgow Royal Infirmary,Great Ormond Street Hospital,University of South Florida,University Hospital Heidelberg,The Breast Cancer Research Foundation,University of Porto,University Malaya Medical Centre,Latvian Biomedical Research and Study centre,Cancer Epidemiology Unit,National and Kapodistrian University of Athens,Beth Israel Deaconess Medical Center,University Medical Center Groningen,Charité,University of Santiago de Compostela,Vanderbilt University Medical Center,Churchill Hospital,University of Ulm,Leiden University Medical Center,University of Virginia,University of New South Wales,Garvan Institute of Medical Research,Sapienza University of Rome,Seoul National University,Medical University of South Carolina,Yale University

- 01 May 2017 -

Nature Genetics

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TL;DR: Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.

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Journal ArticleDOI

CDK 4/6 Inhibitor Palbociclib (PD0332991) in Rb+ Advanced Breast Cancer: Phase II Activity, Safety and Predictive Biomarker Assessment

Angela DeMichele,Amy S. Clark,Kay See Tan,Daniel F. Heitjan,Kristi Gramlich,Maryann Gallagher,Priti Lal,Michael Feldman,Paul J. Zhang,Christopher Colameco,David A. Lewis,Melissa Langer,Noah Goodman,Susan M. Domchek,Keerthi Gogineni,Mark A. Rosen,Kevin Fox,Peter O'Dwyer +17 moreUniversity of Pennsylvania

- 01 Mar 2015 -

Clinical Cancer Research

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TL;DR: Single-agent palbociclib is well tolerated and active in patients with endocrine-resistant, HR+, Rb-positive breast cancer and no biomarker identified a sensitive tumor population.

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Journal ArticleDOI

A Population-Based Study of Genes Previously Implicated in Breast Cancer

Chunling Hu,Steven N. Hart,Rohan Gnanaolivu,Hongyan Huang,Kun Y. Lee,Jie Na,Chi Gao,Jenna Lilyquist,Siddhartha Yadav,Nicholas J. Boddicker,Raed Samara,Josh Klebba,Christine B. Ambrosone,Hoda Anton-Culver,Paul L. Auer,Elisa V. Bandera,Leslie Bernstein,Kimberly A. Bertrand,Elizabeth S. Burnside,Brian D. Carter,Heather Eliassen,Susan M. Gapstur,Mia M. Gaudet,Christopher A. Haiman,James M. Hodge,David J. Hunter,David J. Hunter,Eric J. Jacobs,Esther M. John,Charles Kooperberg,Allison W. Kurian,Loic Le Marchand,Sara Lindstroem,Tricia Lindstrom,Huiyan Ma,Susan L. Neuhausen,Polly A. Newcomb,Katie M. O'Brien,Janet E. Olson,Irene M. Ong,Tuya Pal,Julie R. Palmer,Alpa V. Patel,Sonya Reid,Lynn Rosenberg,Dale P. Sandler,Christopher G. Scott,Rulla M. Tamimi,Jack A. Taylor,Amy Trentham-Dietz,Celine M. Vachon,Clarice R. Weinberg,Song Yao,Argyrios Ziogas,Jeffrey N. Weitzel,David E. Goldgar,Susan M. Domchek,Katherine L. Nathanson,Peter Kraft,Eric C. Polley,Fergus J. Couch +60 moreMayo Clinic,Harvard University,Roswell Park Cancer Institute,University of California, Irvine,University of Wisconsin–Milwaukee,Rutgers University,City of Hope National Medical Center,Boston University,University of Wisconsin-Madison,American Cancer Society,University of Southern California,University of Oxford,Stanford University,Fred Hutchinson Cancer Research Center,University of Washington,National Institutes of Health,Vanderbilt University,Cornell University,University of Utah,University of Pennsylvania

- 04 Feb 2021 -

The New England Journal of Medicine

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TL;DR: In this paper, population-based estimates of the risk of breast cancer associated with germline pathogenic variants in cancer-predisposition genes are critically needed for risk assessment and risk assessment.

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Journal ArticleDOI

CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients

Andrew J. Rech,Rosemarie Mick,Sunil Martin,Adri Recio,Nicole A. Aqui,Daniel J. Powell,Theresa A. Colligon,Jennifer A. Trosko,L. Leinbach,Charles H. Pletcher,Carol Kaplan Tweed,Angela DeMichele,Kevin Fox,Susan M. Domchek,James L. Riley,Robert H. Vonderheide +15 moreUniversity of Pennsylvania

- 16 May 2012 -

Science Translational Medicine

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TL;DR: It is concluded that CD25 blockade depletes and selectively reprograms Tregs in concert with active immune therapy in cancer patients, suggesting a mechanism to target cancer-associated T Regs while avoiding autoimmunity.

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Journal ArticleDOI

Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers

Antonis Antoniou,Antonis Antoniou,Amanda B. Spurdle,Amanda B. Spurdle,Olga M. Sinilnikova,Olga M. Sinilnikova,Sue Healey,Sue Healey,Karen A. Pooley,Karen A. Pooley,Rita K. Schmutzler,Rita K. Schmutzler,Beatrix Versmold,Beatrix Versmold,Christoph Engel,Christoph Engel,Alfons Meindl,Alfons Meindl,Norbert Arnold,Norbert Arnold,W. Hofmann,W. Hofmann,Christian Sutter,Christian Sutter,Dieter Niederacher,Dieter Niederacher,Helmut Deissler,Helmut Deissler,Trinidad Caldés,Trinidad Caldés,Kati Kämpjärvi,Kati Kämpjärvi,Heli Nevanlinna,Heli Nevanlinna,Jacques Simard,Jacques Simard,Jonathan Beesley,Jonathan Beesley,Xiaoqing Chen,Xiaoqing Chen,Susan L. Neuhausen,Susan L. Neuhausen,Timothy R. Rebbeck,Timothy R. Rebbeck,Theresa Wagner,Theresa Wagner,Henry T. Lynch,Claudine Isaacs,Claudine Isaacs,Jeffrey N. Weitzel,Jeffrey N. Weitzel,Patricia A. Ganz,Patricia A. Ganz,Mary B. Daly,Mary B. Daly,Gail E. Tomlinson,Gail E. Tomlinson,Olufunmilayo I. Olopade,Joanne L. Blum,Joanne L. Blum,Fergus J. Couch,Paolo Peterlongo,Siranoush Manoukian,M. Barile,Paolo Radice,Csilla Szabo,Lutecia Pereira,Lutecia Pereira,Mark H. Greene,Mark H. Greene,Gad Rennert,Gad Rennert,Flavio Lejbkowicz,Flavio Lejbkowicz,Ofra Barnett-Griness,Ofra Barnett-Griness,Irene L. Andrulis,Irene L. Andrulis,Irene L. Andrulis,Hilmi Ozcelik,Hilmi Ozcelik,Anne-Marie Gerdes,Anne-Marie Gerdes,Maria A. Caligo,Maria A. Caligo,Yael Laitman,Bella Kaufman,Bella Kaufman,Roni Milgrom,Eitan Friedman,Eitan Friedman,Susan M. Domchek,Katherine L. Nathanson,Ana Osorio,Gemma Llort,Roger L. Milne,Javier Benítez,Javier Benítez,Ute Hamann,Frans B L Hogervorst,Frans B L Hogervorst,Peggy Manders,Marjolijn J L Ligtenberg,Ans M.W. van den Ouweland,Susan Peock,Susan Peock,M. Cook,M. Cook,Radka Platte,Radka Platte,D. Gareth Evans,Rosalind A. Eeles,Gabriella Pichert,Carol Chu,Diana Eccles,Rosemarie Davidson,Fiona Douglas,Andrew K. Godwin,Andrew K. Godwin,Laure Barjhoux,Laure Barjhoux,Sylvie Mazoyer,Sylvie Mazoyer,Hagay Sobol,Violaine Bourdon,François Eisinger,Agnès Chompret,Agnès Chompret,Corinne Capoulade,Brigitte Bressac-de Paillerets,Gilbert M. Lenoir,Marion Gauthier-Villars,Claude Houdayer,Dominique Stoppa-Lyonnet,Georgia Chenevix-Trench,Georgia Chenevix-Trench,Douglas F. Easton,Douglas F. Easton +137 morePeter MacCallum Cancer Centre,Cancer Research UK,QIMR Berghofer Medical Research Institute,Claude Bernard University Lyon 1,University of Cologne,Leipzig University,Technische Universität München,University of Kiel,Charité,Heidelberg University,University of Düsseldorf,University of Ulm,Complutense University of Madrid,University of Helsinki,Laval University,University of California, Irvine,University of Pennsylvania,University of Vienna,Creighton University,Georgetown University,City of Hope National Medical Center,University of California, Los Angeles,Fox Chase Cancer Center,University of Texas at Dallas,University of Chicago,Baylor University Medical Center,Mayo Clinic,National Institutes of Health,Clalit Health Services,University of Toronto,Cancer Care Ontario,University of Southern Denmark,University of Pisa,Sheba Medical Center,Carlos III Health Institute,Netherlands Cancer Institute,Radboud University Nijmegen Medical Centre,Erasmus University Rotterdam,St Mary's Hospital,Institute of Cancer Research,Guy's Hospital,Princess Anne Hospital,Centre for Life,French Institute of Health and Medical Research,Institut Gustave Roussy,Paris Descartes University

- 11 Apr 2008 -

American Journal of Human Genetics

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TL;DR: Differences in the effects of the FGFR2 and MAP3K1 SNPs between BRCA1 and BRCa2 carriers point to differences in the biology of BRC a1 and bRCA2 breast cancer tumors and confirm the distinct nature of breast cancer in BRC A1 mutation carriers.

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