Susan M. Domchek

TL;DR: It is demonstrated that acceptance of BRCA1/2 test results may be limited among African American women, and being married and having less certainty about one's cancer risk may motivate acceptance of the test results.

TL;DR: In this article, the authors assess whether exercise intervention in premenopausal women at increased breast cancer risk reduces estrogen or progesterone levels, and the results suggest value in exercise interventions to reduce hormone levels in high-risk women with few side effects and the potential for incremental benefits to surgical or pharmacologic interventions.

TL;DR: Population-based PRS are strongly associated with BC and EOC risks for BRCA1/2 carriers and predict substantial absolute risk differences for women at PRS distribution extremes, and there was evidence for differences in associations by predicted variant effects on protein expression.

TL;DR: The combination of olaparib and durvalumab was well tolerated and showed promising median PFS and DoR, and this cohort has been expanded to further explore the durability of this chemotherapy-sparing combination.

TL;DR: Bilateral prophylactic salpingo-oophorectomy is widely used for cancer risk reduction in women with BRCA1/2 mutations but may be accompanied by menopausal symptoms, impaired quality of life and accelerated bone loss.