E
Eunhee Kim
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 31
Citations - 3382
Eunhee Kim is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Myeloid & Haematopoiesis. The author has an hindex of 18, co-authored 27 publications receiving 2784 citations. Previous affiliations of Eunhee Kim include Cleveland Clinic.
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Journal ArticleDOI
RNA splicing factors as oncoproteins and tumour suppressors
TL;DR: The recent genomic characterization of cancers has revealed recurrent somatic point mutations and copy number changes affecting genes encoding RNA splicing factors, which may create novel vulnerabilities in cancer cells that can be therapeutic exploited using compounds that can influence the splicing process.
Journal ArticleDOI
SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition
Eunhee Kim,Janine O. Ilagan,Yang Liang,Gerrit M. Daubner,Stanley Chun-Wei Lee,Aravind Ramakrishnan,Aravind Ramakrishnan,Yue Li,Young Rock Chung,Jean Baptiste Micol,Michele E. Murphy,Hana Cho,Min Kyung Kim,Ahmad S. Zebari,Shlomzion Aumann,Christopher Y. Park,Silvia Buonamici,Pete Smith,H. Joachim Deeg,H. Joachim Deeg,Camille Lobry,Camille Lobry,Iannis Aifantis,Yorgo Modis,Yorgo Modis,Frédéric H.-T. Allain,Stephanie Halene,Robert K. Bradley,Omar Abdel-Wahab +28 more
TL;DR: It is reported that mutations affecting the splicing factor S RSF2 directly impair hematopoietic differentiation in vivo, which is not due to SRSF2 loss of function, and this data provide a mechanistic link between a mutant spliceosomal protein, alterations in thesplicing of key regulators, and impaired hematoiesis.
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Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms
Eli L. Diamond,Benjamin H. Durham,Julien Haroche,Zhan Yao,Jing Ma,Sameer A. Parikh,Zhaoming Wang,John K. Choi,Eunhee Kim,Fleur Cohen-Aubart,Stanley Chun-Wei Lee,Yijun Gao,Jean Baptiste Micol,Patrick Campbell,Michael P. Walsh,Brooke E. Sylvester,Igor Dolgalev,Olga Aminova,Adriana Heguy,Paul Zappile,Joy Nakitandwe,Chezi Ganzel,James Dalton,David W. Ellison,Juvianee Estrada-Veras,Mario E. Lacouture,William A. Gahl,Philip J. Stephens,Vincent A. Miller,Jeffrey S. Ross,Siraj M. Ali,Samuel Briggs,Omotayo Fasan,Jared Block,Sébastien Héritier,Jean Donadieu,David B. Solit,David M. Hyman,José Baselga,Filip Janku,Barry S. Taylor,Christopher Y. Park,Zahir Amoura,Ahmet Dogan,Jean-François Emile,Neal Rosen,Tanja A. Gruber,Omar Abdel-Wahab +47 more
TL;DR: Refractory patients with MAP2K1- and ARAF-mutant histiocytoses had clinical responses to MEK inhibition and sorafenib, respectively, highlighting the importance of comprehensive genomic analysis of these disorders.
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Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
Omar Abdel-Wahab,Jie Gao,Mazhar Adli,Anwesha Dey,Thomas Trimarchi,Young Rock Chung,Cem Kuscu,Todd Hricik,Delphine Ndiaye-Lobry,Lindsay M. LaFave,Richard Koche,Richard Koche,Alan H. Shih,Olga A. Guryanova,Eunhee Kim,Sheng Li,Suveg Pandey,Joseph Y. Shin,Leon Telis,Jinfeng Liu,Parva K. Bhatt,Sebastien Monette,Xinyang Zhao,Christopher E. Mason,Christopher Y. Park,Bradley E. Bernstein,Bradley E. Bernstein,Iannis Aifantis,Ross L. Levine,Ross L. Levine +29 more
TL;DR: Loss of Asxl1 results in myelodysplastic syndrome, whereas concomitant deletion of Tet2 restores HSC self-renewal and triggers a more severe disease phenotype distinct from that seen in single-gene knockout mice.
Journal ArticleDOI
Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.
Stanley Chun-Wei Lee,Heidi Dvinge,Eunhee Kim,Hana Cho,Jean-Baptiste Micol,Young Rock Chung,Benjamin H. Durham,Akihide Yoshimi,Young Joon Kim,Michael P. Thomas,Camille Lobry,Chun-Wei Chen,Alessandro Pastore,Justin Taylor,Xujun Wang,Andrei V. Krivtsov,Scott A. Armstrong,James Palacino,Silvia Buonamici,Pete Smith,Robert K. Bradley,Omar Abdel-Wahab +21 more
TL;DR: Genetic and pharmacologic evidence is provided that leukemias with spliceosomal gene mutations are preferentially susceptible to additional splicing perturbations in vivo as compared to leukedmias without such mutations, and modulation of splicesome function may provide a new therapeutic avenue in genetically defined subsets of individuals with MDS or AML.