S
Sylvain Normand
Researcher at university of lille
Publications - 9
Citations - 1204
Sylvain Normand is an academic researcher from university of lille. The author has contributed to research in topics: Colitis & Inflammation. The author has an hindex of 8, co-authored 9 publications receiving 1035 citations. Previous affiliations of Sylvain Normand include French Institute of Health and Medical Research & Lille University of Science and Technology.
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Journal ArticleDOI
NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer
Aurélie Couturier-Maillard,Thomas Secher,Ateequr Rehman,Sylvain Normand,Adèle De Arcangelis,Robert Haesler,Ludovic Huot,Teddy Grandjean,Aude Bressenot,Anne Delanoye-Crespin,Olivier Gaillot,Stefan Schreiber,Yves Lemoine,Bernhard Ryffel,David Hot,Gabriel Núñez,Grace Y. Chen,Philip Rosenstiel,Mathias Chamaillard +18 more
TL;DR: It is shown that dysbiosis caused by Nod2 deficiency gives rise to a reversible, communicable risk of colitis and colitis-associated carcinogenesis in mice, and manipulation of dysbiotic microbiota is a potential therapeutic approach in the treatment of human intestinal disorders.
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Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury
Sylvain Normand,Anne Delanoye-Crespin,Aude Bressenot,Ludovic Huot,Teddy Grandjean,Laurent Peyrin-Biroulet,Yves Lemoine,David Hot,Mathias Chamaillard +8 more
TL;DR: It is demonstrated that Nod-like receptor pyrin domain-containing protein 6 (NLRP6) suppresses inflammation and carcinogenesis by regulating tissue repair and the integrity of the epithelial barrier is preserved by NLRP6 that may be manipulated to develop drugs capable of preventing adenoma formation in inflammatory bowel diseases.
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Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice
Mamdouh A.K. Sedhom,M. Pichery,Jenna R. Murdoch,Benoît Foligné,Nathalie Ortega,Sylvain Normand,Kirsten D. Mertz,Devika Sanmugalingam,Lea Brault,Teddy Grandjean,Emma Lefrançais,Padraic G. Fallon,Valérie Quesniaux,Laurent Peyrin-Biroulet,Gieri Cathomas,Tobias Junt,Mathias Chamaillard,Jean-Philippe Girard,Bernhard Ryffel +18 more
TL;DR: A novel non-hematopoietic function of IL-33 in epithelial barrier function and wound healing is unveiled, and blocking the IL- 33/ST2 axis may represent an efficient therapy in IBD.
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Pseudomonas aeruginosa type-3 secretion system dampens host defense by exploiting the NLRC4-coupled inflammasome.
Emmanuel Faure,Jean-Baptiste Mear,Karine Faure,Sylvain Normand,Aurélie Couturier-Maillard,Teddy Grandjean,Viviane Balloy,Bernhard Ryffel,Rodrigue Dessein,Michel Chignard,Catherine Uyttenhove,Benoit Guery,Philippe Gosset,Mathias Chamaillard,Eric Kipnis +14 more
TL;DR: Through NLRC4 inflammasome activation, the T3SS promotes IL-18 secretion, which dampens a beneficial IL-17-mediated antimicrobial host response.
Journal ArticleDOI
Hemidesmosome integrity protects the colon against colitis and colorectal cancer
Adèle De Arcangelis,Hussein Hamade,Fabien Alpy,Sylvain Normand,Emilie Bruyère,Olivier Lefebvre,Agnès Méchine-Neuville,Stéphanie Siebert,Véronique Pfister,Patricia Lepage,Patrice Laquerriere,Patrice Laquerriere,Doulaye Dembélé,Anne Delanoye-Crespin,Sophie Rodius,Sylvie Robine,Sylvie Robine,Michèle Kedinger,Michèle Kedinger,Isabelle Van Seuningen,Patricia Simon-Assmann,Mathias Chamaillard,Michel Labouesse,Elisabeth Georges-Labouesse +23 more
TL;DR: Evidence is provided for the first time evidence that loss of IECs/BM interactions triggered by hemidesmosome disruption initiates the development of inflammatory lesions that progress into high-grade dysplasia and carcinoma.