S
Sylvaine Cases
Researcher at University of California, San Francisco
Publications - 29
Citations - 6135
Sylvaine Cases is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Sterol O-acyltransferase & Nucleic acid. The author has an hindex of 17, co-authored 29 publications receiving 5749 citations. Previous affiliations of Sylvaine Cases include University of California & Veterans Health Administration.
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Journal ArticleDOI
Triglyceride accumulation protects against fatty acid-induced lipotoxicity
Laura L. Listenberger,Xianlin Han,Sarah Lewis,Sylvaine Cases,Robert V. Farese,Daniel S. Ory,Jean E. Schaffer +6 more
TL;DR: This work demonstrates in cultured cells that the relative toxicity of two common dietary long chain fatty acids is related to channeling of these lipids to distinct cellular metabolic fates, and supports a model of cellular lipid metabolism in which unsaturated fatty acids serve a protective function against lipotoxicity though promotion of triglyceride accumulation.
Journal ArticleDOI
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
Sylvaine Cases,Steven J. Smith,Yaowu Zheng,Heather M. Myers,Steven R. Lear,Eric Sande,Sabine Novak,Colin Collins,Carrie B. Welch,Aldons J. Lusis,Sandra K. Erickson,Robert V. Farese +11 more
TL;DR: An expressed sequence tag clone that shared regions of similarity with acyl CoA:cholesterol acyltransferase, an enzyme that also uses fatty acyl coA as a substrate was identified, which will greatly facilitate studies of cellular glycerolipid metabolism and its regulation.
Journal ArticleDOI
Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat.
Steven J. Smith,Sylvaine Cases,Dalan R. Jensen,Hubert Chen,Eric Sande,Bryan Tow,David A. Sanan,Jacob Raber,Robert H. Eckel,Robert V. Farese +9 more
TL;DR: It is shown that Dgat-deficient (Dgat−/−) mice are viable and can still synthesize triglycerides, and these mice are lean and resistant to diet-induced obesity.
Journal ArticleDOI
Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members
Sylvaine Cases,S. Stone,Ping Zhou,Eric Yen,Bryan Tow,Kathryn D. Lardizabal,Toni Voelker,Robert V. Farese +7 more
TL;DR: A second mammalian DGAT, DGAT2, is cloned and characterized, which was identified by its homology to a DGAT in the fungus Mortierella rammaniana, suggesting that it may play a significant role in mammalian triglyceride metabolism.
Journal ArticleDOI
ACAT-2, A Second Mammalian Acyl-CoA:Cholesterol Acyltransferase ITS CLONING, EXPRESSION, AND CHARACTERIZATION
Sylvaine Cases,Sabine Novak,Yaowu Zheng,Heather M. Myers,Steven R. Lear,Steven R. Lear,Eric Sande,Carrie B. Welch,Aldons J. Lusis,Thomas A. Spencer,Brian R. Krause,Sandra K. Erickson,Sandra K. Erickson,Robert V. Farese +13 more
TL;DR: A second mammalian ACAT enzyme is described, designated ACAT-2, that is 44% identical to the first cloned mouse ACAT (henceforth designated ACat-1) and will facilitate molecular approaches to understanding the role of ACAT enzymes in mammalian biology.