S
Shensi Shen
Researcher at Institut Gustave Roussy
Publications - 55
Citations - 5769
Shensi Shen is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Autophagy & Programmed cell death. The author has an hindex of 29, co-authored 48 publications receiving 4841 citations. Previous affiliations of Shensi Shen include University of Paris-Sud & Centre national de la recherche scientifique.
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Journal ArticleDOI
Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice.
Mickaël Michaud,Mickaël Michaud,Mickaël Michaud,Isabelle Martins,Isabelle Martins,Isabelle Martins,Abdul Qader Sukkurwala,Abdul Qader Sukkurwala,Abdul Qader Sukkurwala,Sandy Adjemian,Sandy Adjemian,Sandy Adjemian,Yuting Ma,Patrizia Pellegatti,Shensi Shen,Shensi Shen,Shensi Shen,Oliver Kepp,Oliver Kepp,Oliver Kepp,Marie Scoazec,Grégoire Mignot,Santiago Rello-Varona,Santiago Rello-Varona,Santiago Rello-Varona,Maximilien Tailler,Maximilien Tailler,Maximilien Tailler,Laurie Menger,Laurie Menger,Laurie Menger,Erika Vacchelli,Erika Vacchelli,Erika Vacchelli,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,François Ghiringhelli,Francesco Di Virgilio,Laurence Zitvogel,Guido Kroemer +40 more
TL;DR: It is demonstrated that autophagy, which is often disabled in cancer, is dispensable for chemotherapy-induced cell death but required for its immunogenicity, and increased extracellular ATP concentrations improve the efficacy of antineoplastic chemotherapies when Autophagy is disabled.
Journal ArticleDOI
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
Eugenia Morselli,Guillermo Mariño,Guillermo Mariño,Guillermo Mariño,Martin V. Bennetzen,Tobias Eisenberg,Evgenia Megalou,Sabrina Schroeder,Sandra Cabrera,Paule Bénit,Pierre Rustin,Alfredo Criollo,Alfredo Criollo,Alfredo Criollo,Oliver Kepp,Oliver Kepp,Oliver Kepp,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Shensi Shen,Shensi Shen,Shensi Shen,Shoaib Ahmad Malik,Shoaib Ahmad Malik,Shoaib Ahmad Malik,Maria Chiara Maiuri,Maria Chiara Maiuri,Maria Chiara Maiuri,Yoshiyuki Horio,Carlos López-Otín,Jens S. Andersen,Nektarios Tavernarakis,Frank Madeo,Guido Kroemer +34 more
TL;DR: The acetylase inhibitor spermidine and the sirtuin-1 activator resveratrol disrupt the antagonistic network of acetylases and deacetylases that regulate autophagy.
Journal ArticleDOI
Molecular mechanisms of ATP secretion during immunogenic cell death
Isabelle Martins,Wang Y,Wang Y,Wang Y,Mickaël Michaud,Mickaël Michaud,Mickaël Michaud,Yuting Ma,Yuting Ma,Yuting Ma,Abdul Qader Sukkurwala,Abdul Qader Sukkurwala,Abdul Qader Sukkurwala,Shensi Shen,Shensi Shen,Shensi Shen,Oliver Kepp,Oliver Kepp,Oliver Kepp,Didier Métivier,Didier Métivier,Didier Métivier,Lorenzo Galluzzi,Lorenzo Galluzzi,J-L Perfettini,J-L Perfettini,J-L Perfettini,Laurence Zitvogel,Guido Kroemer +28 more
TL;DR: It is shown that caspase- and PANX1-dependent lysosomal exocytosis has an essential role in ATP release as triggered by immunogenic chemotherapy, and suggests that autophagy-deficient cancer cells fail to elicit therapy-relevant immune responses in vivo.
Journal ArticleDOI
An immunosurveillance mechanism controls cancer cell ploidy
Laura Senovilla,Laura Senovilla,Laura Senovilla,Ilio Vitale,Ilio Vitale,Ilio Vitale,Isabelle Martins,Isabelle Martins,Isabelle Martins,Maximilien Tailler,Maximilien Tailler,Maximilien Tailler,Claire Pailleret,Claire Pailleret,Claire Pailleret,Mickaël Michaud,Mickaël Michaud,Mickaël Michaud,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Sandy Adjemian,Sandy Adjemian,Sandy Adjemian,Oliver Kepp,Oliver Kepp,Oliver Kepp,Mireia Niso-Santano,Mireia Niso-Santano,Mireia Niso-Santano,Shensi Shen,Shensi Shen,Shensi Shen,Guillermo Mariño,Guillermo Mariño,Guillermo Mariño,Alfredo Criollo,Alfredo Criollo,Alfredo Criollo,Alice Boilève,Alice Boilève,Alice Boilève,Bastien Job,Sylvain Ladoire,François Ghiringhelli,Antonella Sistigu,Antonella Sistigu,Antonella Sistigu,Takahiro Yamazaki,Takahiro Yamazaki,Takahiro Yamazaki,Santiago Rello-Varona,Santiago Rello-Varona,Santiago Rello-Varona,Clara Locher,Clara Locher,Clara Locher,Vichnou Poirier-Colame,Vichnou Poirier-Colame,Vichnou Poirier-Colame,Monique Talbot,Alexander Valent,Francesco Berardinelli,Antonio Antoccia,Fabiola Ciccosanti,Gian Maria Fimia,Mauro Piacentini,Antonio Fueyo,Nicole L Messina,Nicole L Messina,Ming Li,Christopher J. Chan,Christopher J. Chan,Verena Sigl,Guillaume Pourcher,Guillaume Pourcher,Christoph Ruckenstuhl,Didac Carmona-Gutierrez,Vladimir Lazar,Josef M. Penninger,Frank Madeo,Carlos López-Otín,Mark J. Smyth,Mark J. Smyth,Laurence Zitvogel,Maria Castedo,Maria Castedo,Maria Castedo,Guido Kroemer +88 more
TL;DR: It is reported that hyperploid cancer cells become immunogenic because of a constitutive endoplasmic reticulum stress response resulting in the aberrant cell surface exposure of calreticulin, which causes recognition of cancer cells in mice by the host immune system.
Journal ArticleDOI
Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death
Laurie Menger,Erika Vacchelli,Erika Vacchelli,Erika Vacchelli,Sandy Adjemian,Sandy Adjemian,Sandy Adjemian,Isabelle Martins,Isabelle Martins,Isabelle Martins,Yuting Ma,Yuting Ma,Yuting Ma,Shensi Shen,Shensi Shen,Shensi Shen,Takahiro Yamazaki,Takahiro Yamazaki,Takahiro Yamazaki,Abdul Qader Sukkurwala,Abdul Qader Sukkurwala,Abdul Qader Sukkurwala,Mickaël Michaud,Mickaël Michaud,Mickaël Michaud,Grégoire Mignot,Frédéric Schlemmer,Frédéric Schlemmer,Frédéric Schlemmer,Eric Sulpice,Clara Locher,Clara Locher,Clara Locher,Xavier Gidrol,François Ghiringhelli,Nazanine Modjtahedi,Nazanine Modjtahedi,Nazanine Modjtahedi,Lorenzo Galluzzi,Lorenzo Galluzzi,Fabrice Andre,Fabrice Andre,Laurence Zitvogel,Laurence Zitvogel,Laurence Zitvogel,Oliver Kepp,Oliver Kepp,Oliver Kepp,Guido Kroemer +48 more
TL;DR: Rec retrospective clinical analyses revealed that the administration of the CG digoxin during chemotherapy had a positive impact on overall survival in cohorts of breast, colorectal, head and neck, and hepatocellular carcinoma patients, especially when they were treated with agents other than anthracyclines and oxaliplatin.