T
Tadanori Mammoto
Researcher at Medical College of Wisconsin
Publications - 118
Citations - 11869
Tadanori Mammoto is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Angiogenesis & Extracellular matrix. The author has an hindex of 40, co-authored 110 publications receiving 10390 citations. Previous affiliations of Tadanori Mammoto include Beth Israel Deaconess Medical Center & Boston Children's Hospital.
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Journal ArticleDOI
Soluble endoglin contributes to the pathogenesis of preeclampsia.
Shivalingappa Venkatesha,Mourad Toporsian,Chun Lam,Jun-ichi Hanai,Tadanori Mammoto,Yeon Mee Kim,Yeon Mee Kim,Yuval Bdolah,Kee-Hak Lim,Hai Tao Yuan,Towia A. Libermann,Isaac E. Stillman,Drucilla J. Roberts,Patricia A. D'Amore,Franklin H. Epstein,Frank W. Sellke,Roberto Romero,Roberto Romero,Vikas P. Sukhatme,Michelle Letarte,S. Ananth Karumanchi +20 more
TL;DR: A novel placenta-derived soluble TGF-β coreceptor, endoglin (sEng), which is elevated in the sera of preeclamptic individuals, correlates with disease severity and falls after delivery, suggest that sEng may act in concert with sFlt1 to induce severe preeclampsia.
Journal ArticleDOI
BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injury
Michael Zeisberg,Jun-ichi Hanai,Hikaru Sugimoto,Tadanori Mammoto,David M. Charytan,Frank Strutz,Raghu Kalluri +6 more
TL;DR: It is reported that BMP-7 reverses TGF-β1–induced epithelial-to-mesenchymal transition (EMT) by reinduction of E-cadherin, a key epithelial cell adhesion molecule, which provides evidence of cross talk between B MP-7 and TGF -β1 in the regulation of EMT in health and disease.
Journal ArticleDOI
Mechanical control of tissue and organ development
TL;DR: Work based on the convergence of physics, engineering and biology that suggests that mechanical forces generated by living cells are as crucial as genes and chemical signals for the control of embryological development, morphogenesis and tissue patterning is reviewed.
Journal ArticleDOI
A mechanosensitive transcriptional mechanism that controls angiogenesis
Akiko Mammoto,Kip M. Connor,Tadanori Mammoto,Chong W. Yung,Dongeun Huh,C. M. Aderman,Gustavo Mostoslavsky,Gustavo Mostoslavsky,Lois E.H. Smith,Donald E. Ingber +9 more
TL;DR: This work shows that the Rho inhibitor, p190RhoGAP (also known as GRLF1), controls capillary network formation in vitro in human microvascular endothelial cells and retinal angiogenesis in vivo by modulating the balance of activities between two antagonistic transcription factors.
Journal ArticleDOI
Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans.
Samir M. Parikh,Tadanori Mammoto,Aylit Schultz,Hai Tao Yuan,David C. Christiani,S. Ananth Karumanchi,Vikas P. Sukhatme +6 more
TL;DR: A critical role is identified in disrupting normal pulmonary endothelial function in sepsis-associated lung injury and excess systemic Ang-2 provokes pulmonary leak and congestion in otherwise healthy adult mice.