T
Tadashi Baba
Researcher at Juntendo University
Publications - 50
Citations - 6694
Tadashi Baba is an academic researcher from Juntendo University. The author has contributed to research in topics: Staphylococcus aureus & Genome. The author has an hindex of 26, co-authored 50 publications receiving 6270 citations. Previous affiliations of Tadashi Baba include University of California, Los Angeles & Kyoto University.
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Journal ArticleDOI
Whole genome sequencing of meticillin-resistant Staphylococcus aureus
Makoto Kuroda,Toshiko Ohta,Ikuo Uchiyama,Tadashi Baba,Harumi Yuzawa,Ichizo Kobayashi,Longzhu Cui,Akio Oguchi,Ken-ichi Aoki,Yoshimi Nagai,JianQi Lian,Teruyo Ito,Mutsumi Kanamori,Hiroyuki Matsumaru,Atsushi Maruyama,Hiroyuki Murakami,Akira Hosoyama,Yoko Mizutani-Ui,Noriko K. Takahashi,Toshihiko Sawano,Ryu-ichi Inoue,Chikara Kaito,Kazuhisa Sekimizu,Hideki Hirakawa,Satoru Kuhara,Susumu Goto,Junko Yabuzaki,Minoru Kanehisa,Atsushi Yamashita,Kenshiro Oshima,Keiko Furuya,Chie Yoshino,Tadayoshi Shiba,Masahira Hattori,Naotake Ogasawara,Hideo Hayashi,Keiichi Hiramatsu +36 more
TL;DR: Investigation of many newly identified gene products, including the 70 putative virulence factors, will greatly improve the understanding of the biology of staphylococci and the processes of infectious diseases caused by S aureus.
Journal ArticleDOI
Genome and virulence determinants of high virulence community-acquired MRSA.
Tadashi Baba,Fumihiko Takeuchi,Makoto Kuroda,Harumi Yuzawa,Ken-ichi Aoki,Akio Oguchi,Yoshimi Nagai,Natsuko Iwama,Kazuyuki Asano,Timothy S. Naimi,Hiroko Kuroda,Longzhu Cui,Kenji Yamamoto,Keiichi Hiramatsu +13 more
TL;DR: The whole genome sequence of MW2, a strain of community-acquired MRSA, was ascertained by shotgun cloning and sequencing and found that it carried a range of virulence and resistance genes that was distinct from those displayed on the chromosomes of extant S aureus strains.
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Genome Sequence of Staphylococcus aureus Strain Newman and Comparative Analysis of Staphylococcal Genomes: Polymorphism and Evolution of Two Major Pathogenicity Islands
TL;DR: The complete genome sequence of S. aureus Newman is reported, which carries four integrated prophages, as well as two large pathogenicity islands, and the absence of drug resistance genes reflects the general antibiotic-susceptible phenotype of Sengers Newman.
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Whole-Genome Sequencing of Staphylococcus haemolyticus Uncovers the Extreme Plasticity of Its Genome and the Evolution of Human-Colonizing Staphylococcal Species
Fumihiko Takeuchi,Shinya Watanabe,Tadashi Baba,Harumi Yuzawa,Teruyo Ito,Yuh Morimoto,Makoto Kuroda,Longzhu Cui,Mikio Takahashi,Akiho Ankai,Shin-ichi Baba,Shigehiro Fukui,Jean C. Lee,Keiichi Hiramatsu +13 more
TL;DR: The complete genome sequence of S.haemolyticus was determined to better understand its pathogenicity and evolutionary relatedness to the other staphylococcal species, and a region of the bacterial chromosome just downstream of the origin of replication that showed little homology among the species but was conserved among strains within a species.
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Prophages of Staphylococcus aureus Newman and their contribution to virulence.
TL;DR: Four prophages (φNM1–4) were identified in the genome of Staphylococcus aureus Newman, a human clinical isolate and S. aureusNewton lacking all four prophage was unable to cause disease, thereby revealing essential contributions of prophAGE to the pathogenesis of staphylitis infections.