T
Taghreed Hirz
Researcher at University of Texas MD Anderson Cancer Center
Publications - 16
Citations - 1082
Taghreed Hirz is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Tumor microenvironment & Cancer research. The author has an hindex of 6, co-authored 8 publications receiving 654 citations. Previous affiliations of Taghreed Hirz include University of Lyon.
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Journal ArticleDOI
STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma.
Ferdinandos Skoulidis,Michael E. Goldberg,Danielle Greenawalt,Matthew D. Hellmann,Mark M. Awad,Justin F. Gainor,Alexa B. Schrock,Ryan J. Hartmaier,Sally E. Trabucco,Siraj M. Ali,Julia A. Elvin,Gaurav Singal,Jeffrey S. Ross,David Fabrizio,Péter Szabó,Han Chang,Ariella Sasson,Sujaya Srinivasan,Stefan Kirov,Joseph D. Szustakowski,Patrik Vitazka,Robin Edwards,Jose A. Bufill,Neelesh Sharma,Sai-Hong Ignatius Ou,Nir Peled,Nir Peled,David R. Spigel,Hira Rizvi,Elizabeth Jimenez Aguilar,Brett W. Carter,Jeremy J. Erasmus,Darragh Halpenny,Andrew J. Plodkowski,Niamh Long,Mizuki Nishino,Warren Denning,Ana Galan-Cobo,Haifa Hamdi,Taghreed Hirz,Pan Tong,Jing Wang,Jaime Rodriguez-Canales,Pamela Villalobos,Edwin Roger Parra,Neda Kalhor,Lynette M. Sholl,Jennifer L. Sauter,Achim A. Jungbluth,Mari Mino-Kenudson,Roxana Azimi,Yasir Elamin,Jianjun Zhang,Giulia Costanza Leonardi,Fei Jiang,Fei Jiang,Kwok-Kin Wong,J. Jack Lee,Vassiliki A. Papadimitrakopoulou,Ignacio I. Wistuba,Vincent A. Miller,Garrett M. Frampton,Jedd D. Wolchok,Alice T. Shaw,Pasi A. Jänne,Philip J. Stephens,Charles M. Rudin,William J. Geese,Lee A. Albacker,John V. Heymach +69 more
TL;DR: Genomic profiling may enhance the predictive utility of PD-L1 expression and tumor mutation burden and facilitate establishment of personalized combination immunotherapy approaches for genomically defined LUAC subsets.
Journal ArticleDOI
Thiazole derivatives as inhibitors of cyclooxygenases in vitro and in vivo.
Ghewa A. El-Achkar,Mariam Jouni,May F. Mrad,Taghreed Hirz,Nehme El Hachem,Ali Khalaf,Soukaina Hammoud,Hussein Fayyad-Kazan,Assaad A. Eid,Bassam Badran,Raghida Abou Merhi,Ali Hachem,Eva Hamade,Aida Habib +13 more
TL;DR: In this study, the in vitro and in vivo effects of two novel thiazole derivatives compound 1 and compound 2 on prostaglandin E2 production and COX activity in inflammatory settings are investigated and contributes to the design of new anti-inflammatory agents and to the understanding of cyclooxygenase inhibition byThiazole.
Journal ArticleDOI
Targeting of CD40 and PD-L1 Pathways Inhibits Progression of Oral Premalignant Lesions in a Carcinogen-induced Model of Oral Squamous Cell Carcinoma.
Jose Augusto Monteiro de Oliveira Novaes,Taghreed Hirz,Irene Guijarro,Monique B. Nilsson,Marlese Pisegna,Alissa Poteete,Hampartsoum B. Barsoumian,Jared J. Fradette,Limo Nmi Chen,Don L. Gibbons,Xiangjun Tian,Jing Wang,Jeffrey N. Myers,Mark J. McArthur,Diana Bell,William N. William,John V. Heymach +16 more
TL;DR: Data suggest that distinct approaches may be used for targeting different steps in the development of OSCC, and that CD40 agonists merit investigation as potential immunoprevention agents in this setting.
Journal ArticleDOI
Neutrophils protect lymphoma cells against cytotoxic and targeted therapies through CD11b/ICAM-1 binding
Taghreed Hirz,Eva-Laure Matera,Kamel Chettab,Lars Petter Jordheim,Doriane Mathe,Anne Evesque,Justine Esmenjaud,Gilles Salles,Charles Dumontet +8 more
TL;DR: Findings reveal a novel protective mechanism of neoplastic B cells involving innate immune cells which could be pharmacologically targeted to enhance the antitumor effect of therapy.
Journal ArticleDOI
Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents.
Taghreed Hirz,Charles Dumontet +1 more
TL;DR: The role of neutrophils on the sensitivity of lymphoma cells to anti-lymphoma agents is studied using 3-dimensional experiments using basement membrane matrix such as Matrigel to mimic the tumor microenvironment.