T
Tamer M. Ibrahim
Researcher at Kafrelsheikh University
Publications - 44
Citations - 790
Tamer M. Ibrahim is an academic researcher from Kafrelsheikh University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 11, co-authored 34 publications receiving 450 citations. Previous affiliations of Tamer M. Ibrahim include British University in Egypt & University of Tübingen.
Papers
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Journal ArticleDOI
Evaluation and optimization of virtual screening workflows with DEKOIS 2.0--a public library of challenging docking benchmark sets.
TL;DR: The previously introduced DEKOIS methodology is improved with enhanced physicochemical matching, now including the consideration of molecular charges, as well as a more sophisticated elimination of latent actives in the decoy set (LADS).
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Design, synthesis and biological evaluation of novel pyridine derivatives as anticancer agents and phosphodiesterase 3 inhibitors.
Ashraf H. Abadi,Tamer M. Ibrahim,Khaled A.M. Abouzid,Jochen Lehmann,Heather N. Tinsley,Bernard D. Gary,Gary A. Piazza +6 more
TL;DR: An in silico docking experiment indicates the potential involvement of other potential molecular targets such as PIM-1 kinase to explain its tumor cell growth inhibitory activity and there is no direct correlation between PDE3 inhibition and anticancer activity for the prepared compounds.
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Leishmania treatment and prevention: Natural and synthesized drugs.
Adnan A. Bekhit,Adnan A. Bekhit,Eman J. El-Agroudy,Aliaa Helmy,Tamer M. Ibrahim,Amin Shavandi,Alaa El-Din A. Bekhit +6 more
TL;DR: This review focuses on recent findings in drugs used for the treatment of leishmaniasis including; chemical and natural antileishmanial moieties, different potential targets, as well as various trials of vaccination development.
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Synthesis, in silico experiments and biological evaluation of 1,3,4-trisubstituted pyrazole derivatives as antimalarial agents
Adnan A. Bekhit,Adnan A. Bekhit,Manal N. S. Saudi,Ahmed M. M. Hassan,Salwa M. Fahmy,Tamer M. Ibrahim,Doaa A. Ghareeb,Aya M. El-Seidy,Sherry N. Nasralla,Alaa El-Din A. Bekhit +9 more
TL;DR: New 1,3,4-trisubstituted pyrazole derivatives were synthesized and evaluated for their antiplasmodial activity and molecular docking of the most active compounds against the wildtype and quadruple mutant pf DHFR-TS structures rationalized the in vitro antimalarial activity.
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In silico identification of novel SARS-COV-2 2'-O-methyltransferase (nsp16) inhibitors: structure-based virtual screening, molecular dynamics simulation and MM-PBSA approaches.
Mahmoud A. El Hassab,Tamer M. Ibrahim,Sara T. Al-Rashood,Amal Alharbi,Razan O. Eskandrani,Wagdy M. Eldehna +5 more
TL;DR: In this paper, a potential novel inhibitor for SARS COV-2 2'-O-methyltransferase (nsp16) was identified, which is one of the most attractive targets in the virus life cycle, responsible for the viral RNA protection via a cap formation process.