Tara Murty

TL;DR: SNIP CARs as discussed by the authors is a protease-based platform for regulating CAR activity using an FDA-approved small molecule, and it has been shown that drug cessation following toxicity onset reversed toxicity, thereby credentialing the platform as a safety switch.

TL;DR: Intravital microscopy imaging indicates that RT allows for rapid CAR T-cell extravasation from the vasculature and expansion within the tumor microenvironment, leading to a more robust and lasting immunologic response.

TL;DR: This imaging and suicide ablation system can provide insight into CAR T-cell migration and proliferation during clinical trials while serving as a suicide switch to limit potential toxicities.

TL;DR: The “PRC2 clock,” defined as the average DNAm in PRC2 LMRs, is proposed as a universal biomarker of cellular aging in somatic cells and demonstrates the application of this biomarker in the evaluation of different anti-aging interventions, including dietary restriction and partial epigenetic reprogramming.

TL;DR: A review of gene editing approaches for T-cell therapy can be found in this paper, which summarizes the current status and near-term potential for translation, as well as a review of the gene editing platforms that have been the best studied in the context of human T-cells and adoptive Tcell therapies.