Y
Yoko Kosaka
Researcher at Oregon Health & Science University
Publications - 18
Citations - 529
Yoko Kosaka is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: T cell & Myeloid leukemia. The author has an hindex of 7, co-authored 14 publications receiving 362 citations. Previous affiliations of Yoko Kosaka include Dartmouth College.
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Journal ArticleDOI
An expanded universe of cancer targets.
William C. Hahn,Joel S. Bader,Theodore P. Braun,Andrea Califano,Paul A. Clemons,Brian J. Druker,Andrew J. Ewald,Haian Fu,Subhashini Jagu,Christopher J. Kemp,William Kim,Calvin J. Kuo,Michael T. McManus,Gordon B. Mills,Xiulei Mo,Nidhi Sahni,Stuart L. Schreiber,Jessica A. Talamas,Pablo Tamayo,Jeffrey W. Tyner,Bridget K. Wagner,William A. Weiss,Daniela S. Gerhard,Vlado Dančík,Shubhroz Gill,Bruce K. Hua,Tanaz Sharifnia,Vasanthi S. Viswanathan,Yilong Zou,Filemon S. Dela Cruz,Andrew L. Kung,Brent R. Stockwell,Jesse S. Boehm,Josh Dempster,Robert T. Manguso,Francisca Vazquez,Lee Cooper,Yuhong Du,Andrey A. Ivanov,Sagar Lonial,Carlos S. Moreno,Qiankun Niu,Taofeek K. Owonikoko,Suresh S. Ramalingam,Matthew A. Reyna,Wei Zhou,Carla Grandori,Ilya Shmulevich,Elizabeth M. Swisher,Jitong Cai,Issac S. Chan,Matthew Dunworth,Yuchen Ge,Dan Georgess,Eloise M. Grasset,Elodie Henriet,Hildur Knutsdottir,Michael G. Lerner,Veena Padmanaban,Matthew C. Perrone,Yasir Suhail,Yohannes Tsehay,Manisha Warrier,Quin Morrow,Tamilla Nechiporuk,Nicola Long,Jennifer Saultz,Andy Kaempf,Jessica Minnier,Cristina E. Tognon,Stephen E. Kurtz,Anupriya Agarwal,Jordana Brown,Kevin Watanabe-Smith,Tania Q. Vu,Thomas Jacob,Yunqi Yan,Bridget Robinson,Evan F. Lind,Yoko Kosaka,Emek Demir,Joseph Estabrook,Michael Grzadkowski,Olga Nikolova,Ken Chen,Ben Deneen,Han Liang,Michael C. Bassik,Asmita Bhattacharya,Kevin C. Brennan,Christina Curtis,Olivier Gevaert,Hanlee P. Ji,Kasper Karlsson,Kremena Karagyozova,Yuan-Hung Lo,Katherine N. Liu,Michitaka Nakano,Anuja Sathe,Amber R. Smith,Kaitlyn Spees,Wing Hing Wong,Kanako Yuki,Matt Hangauer,Dan S. Kaufman,Allan Balmain,Saumya R. Bollam,Wei-Ching Chen,Qi-Wen Fan,Kelly Kersten,Matthew F. Krummel,Yun Rose Li,Marie Menard,Nicole Nasholm,Christin Schmidt,Nina K. Serwas,Hiroyuki Yoda,Alan Ashworth,Sourav Bandyopadhyay,Trevor Bivona,Gabriel Eades,Stefan Oberlin,Neil Tay,Yuhao Wang,Jonathan S. Weissman +124 more
TL;DR: A framework is described for this expanded list of cancer targets, providing novel opportunities for clinical translation and indicating that the diversity of therapeutic targets engendered by non-oncogene dependencies is much larger than the list of recurrently mutated genes.
Journal ArticleDOI
Assembly and Regulation of the CD40 Receptor Complex in Human B Cells
Michelle R. Kuhné,Michael D. Robbins,John E. Hambor,Matthew F. Mackey,Yoko Kosaka,Toshihide Nishimura,Jason P. Gigley,Randolph J. Noelle,David M. Calderhead +8 more
TL;DR: The studies show that the TRAF composition of the CD40 receptor complex can be altered by signals that influence B cell differentiation.
Journal ArticleDOI
Lineage-restricted function of nuclear factor κB-inducing kinase (NIK) in transducing signals via CD40
Norman Y. Garceau,Yoko Kosaka,Sally R. Masters,John E. Hambor,Reiko Shinkura,Tasuku Honjo,Randolph J. Noelle +6 more
TL;DR: It is shown that although NIK is essential for B cell activation, it is dispensable for activation of DCs, providing compelling evidence that different intermediary kinases are used by different cellular lineages to trigger NF-κB activation via CD40.
Journal ArticleDOI
Dendritic Cells Require the NF-κB2 Pathway for Cross-Presentation of Soluble Antigens
Evan F. Lind,Cory L. Ahonen,Anna Wasiuk,Yoko Kosaka,Burkhard Becher,Kathy A. Bennett,Randolph J. Noelle +6 more
TL;DR: It is shown that while MHC class II presentation and in vivo migration of Aly DCs is intact, these cells are unable to cross-prime CD8+ T cells to exogenous Ag, explaining the profound immune unresponsiveness of the Aly mouse.
Journal ArticleDOI
Reversible suppression of T cell function in the bone marrow microenvironment of acute myeloid leukemia.
Adam J. Lamble,Yoko Kosaka,Ted Laderas,Allie Maffit,Andy Kaempf,Lauren K. Brady,Weiwei Wang,Nicola Long,Jennifer N. Saultz,Motomi Mori,David Soong,Clare Lefave,Fei Huang,Homer Adams,Marc M. Loriaux,Cristina E. Tognon,Pierrette Lo,Jeffrey W. Tyner,Guang Fan,Shannon K. McWeeney,Brian J. Druker,Brian J. Druker,Evan F. Lind +22 more
TL;DR: The data demonstrate that AML establishes an immune suppressive environment in the bone marrow, in part through T cell checkpoint function, which supports the development of immune checkpoint therapy to combat this deadly disease.