P
Pierre Nicolas
Researcher at Université Paris-Saclay
Publications - 107
Citations - 6314
Pierre Nicolas is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Gene & Flavobacterium psychrophilum. The author has an hindex of 41, co-authored 99 publications receiving 5596 citations. Previous affiliations of Pierre Nicolas include Academy of Sciences of the Czech Republic & Institut national de la recherche agronomique.
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Journal ArticleDOI
Condition-Dependent Transcriptome Reveals High-Level Regulatory Architecture in Bacillus subtilis
Pierre Nicolas,Ulrike Mäder,Etienne Dervyn,Tatiana Rochat,Aurélie Leduc,Nathalie Pigeonneau,Elena Bidnenko,Elodie Marchadier,Mark Hoebeke,Stéphane Aymerich,Dörte Becher,Paola Bisicchia,Eric Botella,Olivier Delumeau,Geoff Doherty,Emma L. Denham,Mark J. Fogg,Vincent Fromion,Anne Goelzer,Annette Hansen,Elisabeth Härtig,Colin R. Harwood,Georg Homuth,Hanne Østergaard Jarmer,Matthieu Jules,Edda Klipp,Ludovic Le Chat,François Lecointe,Peter J. Lewis,Wolfram Liebermeister,Anika March,Ruben A. T. Mars,Priyanka Nannapaneni,David Noone,Susanne Pohl,Bernd Rinn,Frank Rügheimer,Praveen K. Sappa,Franck Samson,Marc Schaffer,Benno Schwikowski,Leif Steil,Jörg Stülke,Thomas Wiegert,Kevin M. Devine,Anthony J. Wilkinson,Jan Maarten van Dijl,Michael Hecker,Uwe Völker,Philippe Bessières,Philippe Noirot +50 more
TL;DR: The transcriptomes of Bacillus subtilis exposed to a wide range of environmental and nutritional conditions that the organism might encounter in nature are reported, offering an initial understanding of why certain regulatory strategies may be favored during evolution of dynamic control systems.
Journal ArticleDOI
The complete genome sequence of Lactobacillus bulgaricus reveals extensive and ongoing reductive evolution
M. van de Guchte,S. Penaud,Christine Grimaldi,Valérie Barbe,Kevin Bryson,Kevin Bryson,Pierre Nicolas,Corinne Robert,Sophie Oztas,Sophie Mangenot,Arnaud Couloux,Valentin Loux,Rozenn Dervyn,Robert Bossy,Bolotin Ap,Jean-Michel Batto,Theresa L. Walunas,J.-F. Gibrat,Philippe Bessières,Jean Weissenbach,Stanislav Dusko Ehrlich,Emmanuelle Maguin +21 more
TL;DR: The results indicate the adaptation of L. bulgaricus from a plant-associated habitat to the stable protein and lactose-rich milk environment through the loss of superfluous functions and protocooperation with Streptococcus thermophilus.
Journal ArticleDOI
Global Network Reorganization During Dynamic Adaptations of Bacillus subtilis Metabolism
Joerg Martin Buescher,Wolfram Liebermeister,Matthieu Jules,Markus Uhr,Jan Muntel,Eric Botella,Bernd Hessling,Roelco J. Kleijn,Ludovic Le Chat,François Lecointe,Ulrike Mäder,Pierre Nicolas,Sjouke Piersma,Frank Rügheimer,Dörte Becher,Philippe Bessières,Elena Bidnenko,Emma L. Denham,Etienne Dervyn,Kevin M. Devine,Geoff Doherty,Samuel Drulhe,Liza Felicori,Mark J. Fogg,Anne Goelzer,Annette Hansen,Colin R. Harwood,Michael Hecker,Sebastian Hubner,Claus Hultschig,Hanne Østergaard Jarmer,Edda Klipp,Aurélie Leduc,Peter J. Lewis,F. Molina,Philippe Noirot,Sabine Peres,Nathalie Pigeonneau,Susanne Pohl,Simon Rasmussen,Bernd Rinn,Marc Schaffer,Julian Schnidder,Benno Schwikowski,Jan Maarten van Dijl,Patrick Veiga,Sean Walsh,Anthony J. Wilkinson,Jörg Stelling,Stéphane Aymerich,Uwe Sauer +50 more
TL;DR: The responses of a bacterium to changing nutritional conditions are explored and an initial understanding of why certain regulatory strategies may be favored during evolution of dynamic control systems is offered.
Journal ArticleDOI
Antimicrobial peptides from hylid and ranin frogs originated from a 150‐million‐year‐old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain
TL;DR: The presence of antimicrobial peptides with such different structures and spectra of action represents the successful evolution of multidrug defense by providing frogs with maximum protection against infectious microbes and minimizing the chance of microorganisms developing resistance to individual peptides.
Journal ArticleDOI
Complete genome sequence of the fish pathogen Flavobacterium psychrophilum
Eric Duchaud,Mekki Boussaha,Valentin Loux,Jean-François Bernardet,Christian Michel,Brigitte Kerouault,Stanislas Mondot,Pierre Nicolas,Robert Bossy,Christophe Caron,Philippe Bessières,Jean-François Gibrat,Stéphane Claverol,Fabien Dumetz,Michel Le Hénaff,Abdenour Benmansour +15 more
TL;DR: The complete genome sequence of the virulent strain JIP02/86 of Flavobacterium psychrophilum, a widely distributed pathogen of wild and cultured salmonid fish, provides the basis for explaining the relationships of the pathogen to the host and opens new perspectives for the development of more efficient disease control strategies.