Tomohiro Ishimaru

TL;DR: Results suggest that the HCU provides acceptable conditions for mouse phenotypic analysis using CBEF in space, as long as its characteristic features are considered, and is a feasible device for future space experiments.

TL;DR: Clear evidence is provided that although erythropoiesis and blood pressure are negatively controlled through the AT1 receptor inhibition in vivo, the pathways involved are complex and distinct, because eriespythropoiedis is more resistant to AT1 receptors inhibition than blood pressure control.

TL;DR: It is found that histamine is elevated in the plasma of a preclinical mouse model with severe cardiac dysfunction and showed that it acts protectively rather than harmfully on heart and kidney damages in this model, and that a histamine H3 agonist, Imm, prevents the cardiorenal damages.

TL;DR: Evidence is provided that PRMT1 is important for embryonic vascular formation by generating endothelial-specific prmt1-knockout mice that died before embryonic day 15, and whole-mount 3D imaging revealed dilated and segmentalized luminal structures in PrMT1-ECKO fetuses in comparison with those of controls.

TL;DR: It is demonstrated that overexpression of APJ in cardiomyocytes has adverse effects on cardiac function in male and non-pregnant mice and that lactation contributes to the development of postpartumCardiomyopathy in the heart with APJ overeexpression.