T
Tomoko Andoh-Noda
Researcher at Keio University
Publications - 10
Citations - 246
Tomoko Andoh-Noda is an academic researcher from Keio University. The author has contributed to research in topics: Induced pluripotent stem cell & Neural stem cell. The author has an hindex of 5, co-authored 8 publications receiving 190 citations. Previous affiliations of Tomoko Andoh-Noda include University of Yamanashi.
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Journal ArticleDOI
Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage
Tomoko Andoh-Noda,Tomoko Andoh-Noda,Wado Akamatsu,Wado Akamatsu,Kunio Miyake,Takuya Matsumoto,Ryo Yamaguchi,Tsukasa Sanosaka,Yohei Okada,Yohei Okada,Tetsuro Kobayashi,Manabu Ohyama,Kinichi Nakashima,Hiroshi Kurosawa,Takeo Kubota,Hideyuki Okano +15 more
TL;DR: An isogenic RTT-hiPSC model demonstrated that MeCP2 participates in the differentiation of neural cells, and it is suggested that astrocytes, which are required for neuronal homeostasis and function, might be a new target of RTT therapy.
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T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease.
Yoshikuni Tabata,Yoichi Imaizumi,Michiko Sugawara,Tomoko Andoh-Noda,Satoe Banno,Muh Chyi Chai,Takefumi Sone,Kazuto Yamazaki,Masashi Ito,Kappei Tsukahara,Hideyuki Saya,Nobutaka Hattori,Jun Kohyama,Hideyuki Okano +13 more
TL;DR: It is demonstrated that the dysregulation of calcium homeostasis and increased susceptibility to rotenone-induced stress in PD is prevented by T-type calcium channel knockdown or antagonists, which might be a useful target for developing new drugs for PD patients.
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Functional Neurons Generated from T Cell-Derived Induced Pluripotent Stem Cells for Neurological Disease Modeling
Takuya Matsumoto,Koki Fujimori,Tomoko Andoh-Noda,Takayuki Ando,Naoko Kuzumaki,Manabu Toyoshima,Hirobumi Tada,Kent Imaizumi,Mitsuru Ishikawa,Ryo Yamaguchi,Miho Isoda,Zhi Zhou,Shigeto Sato,Tetsuro Kobayashi,Manami Ohtaka,Ken Nishimura,Hiroshi Kurosawa,Takeo Yoshikawa,Takuya Takahashi,Mahito Nakanishi,Manabu Ohyama,Nobutaka Hattori,Wado Akamatsu,Wado Akamatsu,Hideyuki Okano +24 more
TL;DR: A neurosphere-based robust differentiation protocol was developed, which enabledTiPSCs to differentiate into functional neurons, despite differences in global gene expression between TiPSCs and adult human dermal fibroblast-derived iPSCs.
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Chromatin remodeler CHD7 regulates the stem cell identity of human neural progenitors.
MuhChyi Chai,Tsukasa Sanosaka,Hironobu Okuno,Zhi Zhou,Ikuko Koya,Satoe Banno,Tomoko Andoh-Noda,Yoshikuni Tabata,Rieko Shimamura,Tetsutaro Hayashi,Masashi Ebisawa,Yohei Sasagawa,Itoshi Nikaido,Hideyuki Okano,Jun Kohyama +14 more
TL;DR: The function of chromodomain helicase DNA-binding 7 (CHD7) is identified in NE-neural crest bifurcation, thus revealing an etiological link between the central nervous system (CNS) and craniofacial anomalies observed in CHARGE syndrome.
Journal ArticleDOI
MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling
Hideyuki Nakashima,Keita Tsujimura,Koichiro Irie,Takuya Imamura,Cleber A. Trujillo,Masataka Ishizu,Masahiro Uesaka,Miao Pan,Hirofumi Noguchi,Kanako Okada,Kei Aoyagi,Tomoko Andoh-Noda,Hideyuki Okano,Alysson R. Muotri,Kinichi Nakashima +14 more
TL;DR: In this article, the MeCP2/miR-199a axis regulates neural stem/precursor cell (NS/PC) differentiation, and a shift occurs from neuronal to astrocytic differentiation due to the upregulation of a miR- 199a target, Smad1, a downstream transcription factor of bone morphogenetic protein (BMP) signaling.