T
Toshio Suda
Researcher at National University of Singapore
Publications - 606
Citations - 44564
Toshio Suda is an academic researcher from National University of Singapore. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 104, co-authored 580 publications receiving 41069 citations. Previous affiliations of Toshio Suda include Keio University & Nagoya University.
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Journal ArticleDOI
Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche
Fumio Arai,Atsushi Hirao,Masako Ohmura,Hidetaka Sato,Sahoko Matsuoka,Keiyo Takubo,Keisuke Ito,Gou Young Koh,Toshio Suda +8 more
TL;DR: It is demonstrated that HSCs expressing the receptor tyrosine kinase Tie2 are quiescent and antiapoptotic, and comprise a side-population (SP) of H SCs, which adhere to osteoblasts (OBs) in the BM niche.
Journal ArticleDOI
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.
Keisuke Ito,Atsushi Hirao,Atsushi Hirao,Fumio Arai,Keiyo Takubo,Sahoko Matsuoka,Kana Miyamoto,Masako Ohmura,Masako Ohmura,Kazuhito Naka,Kentaro Hosokawa,Yasuo Ikeda,Toshio Suda +12 more
TL;DR: In this paper, the authors show that activation of p38 MAPK in response to increasing levels of reactive oxygen species (ROS) limits the lifespan of HSCs in vivo.
Journal ArticleDOI
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
Keisuke Ito,Atsushi Hirao,Fumio Arai,Sahoko Matsuoka,Keiyo Takubo,Isao Hamaguchi,Kana Nomiyama,Kentaro Hosokawa,Kazuhiro Sakurada,Naomi Nakagata,Yasuo Ikeda,Tak W. Mak,Toshio Suda +12 more
TL;DR: It is shown that ATM has an essential function in the reconstitutive capacity of haematopoietic stem cells (HSCs) but is not as important for the proliferation or differentiation of progenitors, in a telomere-independent manner.
Journal ArticleDOI
Metabolic requirements for the maintenance of self-renewing stem cells
Keisuke Ito,Toshio Suda +1 more
TL;DR: Investigation into the molecular mechanisms and metabolic pathways underlying stem cell self-renewal and differentiation hold great therapeutic promise.
Journal ArticleDOI
Regulation of the HIF-1α level is essential for hematopoietic stem cells
Keiyo Takubo,Nobuhito Goda,Wakako Yamada,Hirono Iriuchishima,Eiji Ikeda,Yoshiaki Kubota,Haruko Shima,Randall S. Johnson,Atsushi Hirao,Makoto Suematsu,Toshio Suda +10 more
TL;DR: It is shown that normal HSCs maintain intracellular hypoxia and stabilize Hypoxia-inducible factor-1 alpha (HIF-1alpha) protein, which indicates that H SCs maintain cell cycle quiescence through the precise regulation of HIF- 1alpha levels.