T
Toshio Suda
Researcher at National University of Singapore
Publications - 606
Citations - 44564
Toshio Suda is an academic researcher from National University of Singapore. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 104, co-authored 580 publications receiving 41069 citations. Previous affiliations of Toshio Suda include Keio University & Nagoya University.
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Journal ArticleDOI
DOCK180 Is a Rac Activator That Regulates Cardiovascular Development by Acting Downstream of CXCR4
Fumiyuki Sanematsu,Masanori Hirashima,Mélanie Laurin,Ryosuke Takii,Akihiko Nishikimi,Keiko Kitajima,Guo Ding,Mamiko Noda,Yuzo Murata,Yoshihiko Tanaka,Sadahiko Masuko,Toshio Suda,Chikara Meno,Jean-François Côté,Takashi Nagasawa,Yoshinori Fukui +15 more
TL;DR: In this article, the role of DOCK180 in cardiovascular development was examined, and it was found that targeted deletion of the Src homology 3 domain in mice leads to embryonic lethality.
Journal ArticleDOI
Differentiation of Arterial and Venous Endothelial Cells and Vascular Morphogenesis
Masanori Hirashima,Toshio Suda +1 more
TL;DR: These insights indicate that the balance of these genetic factors and modification by epigenetic factors such as hemodynamics and oxygen tension are important for proper endothelial cell identities in vascular morphogenesis.
Journal Article
Rat stem cell factor and IL-6 preferentially support the proliferation of c-kit-positive murine hemopoietic cells rather than their differentiation
TL;DR: Morphologic examination confirmed the increase in immature cells after culture with SCF + IL-6 and, therefore, this combination is deemed superior for the expansion of primitive cells in liquid culture.
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Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression
Hirono Iriuchishima,Hirono Iriuchishima,Keiyo Takubo,Sahoko Matsuoka,Ichiro Onoyama,Keiichi I. Nakayama,Yoshihisa Nojima,Toshio Suda +7 more
TL;DR: Data suggest that Fbxw7α sustains HSC dormancy through c-Myc, Notch1, and the mTOR pathways, and represents a promising new tool for ex vivo HSC maintenance.
Journal ArticleDOI
Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells
Yoshiko Matsumoto Ikushima,Fumio Arai,Kentaro Hosokawa,Hirofumi Toyama,Keiyo Takubo,Tomoyuki Furuyashiki,Shuh Narumiya,Toshio Suda +7 more
TL;DR: EP4 is a key receptor for PGE(2)-mediated direct and indirect regulation of HSPCs, and the function of P GE(2)/EP4 signaling in the recovery of the H SPCs after myelosuppression is examined.