Tyler Risom

TL;DR: GDC-0068 is a highly selective, orally bioavailable Akt kinase inhibitor that shows pharmacodynamic inhibition of Akt signaling and robust antitumor activity in human cancer cells in vitro and in vivo.

TL;DR: A global insight is proposed on the probable consistency between morphological evolution in animals and the molecular evolution of miRNA gene activity in the cell using the trends in miRNA conservation to deduce miRNA evolutionary trends in metazoans.

TL;DR: MIBI-TOF (multiplexed ion beam imaging by time of flight) is described, an instrument that uses bright ion sources and orthogonal time-of-flight mass spectrometry to image metal-tagged antibodies at subcellular resolution in clinical tissue sections to interrogate intrapatient heterogeneity in tumor organization in triple-negative breast cancer.

TL;DR: TissueNet as mentioned in this paper is a dataset for training segmentation models that contains more than 1 million manually labeled cells, an order of magnitude more than all previously published segmentation training datasets.

TL;DR: It is shown that drug tolerant persistent cell populations emerge during treatment, and these emergent populations arise through epigenetically mediated cell state transitions rather than sub population selection.