Tyrone J. Summers

TL;DR: The generation and analysis of over 12 megabases of sequence from 12 species, all derived from the genomic region orthologous to a segment of about 1.8 Mb on human chromosome 7 containing ten genes, show conservation reflecting both functional constraints and the neutral mutational events that shaped this genomic region.

TL;DR: A robust and scalable strategy for simultaneously constructing sequence-ready bacterial artificial chromosome (BAC) contig maps from targeted genomic regions has been developed using "universal" oligonucleotide-based hybridization probes designed from sequences that are highly conserved between distantly related species.

TL;DR: The data indicate that the duplications associated with mouse chromosomes 5 and 6 are recent and that the resulting duplicated segments share significant sequence similarity with a series of regions near the centromeres of the mouse chromosomes previously identified by cytogenetic mapping.

TL;DR: Direct and indirect evidence indicates that the recombination rate is, indeed, much higher in PAR1 introns than in X-specific introns, and that the present PAB has persisted since the common ancestor of hominoids, therefore, the mutagenic effect of recombination is far weaker than previously proposed, at least in hominoid PABs.

TL;DR: How the first glimpses of genomic sequence from human chromosome 7 are directly facilitating human-mouse comparative maps and sequence-ready mouse physical maps are described to illustrate how the availability of genomic sequences directly facilitates studies in comparative genomics and genome evolution.