Jyoti Gupta

TL;DR: In this article, the authors performed systematic chromatin and transcriptome profiling in human pancreatic islets and found that stretch enhancers are critical chromatin elements for coordinating cell type-specific regulatory programs.

TL;DR: The generation and analysis of over 12 megabases of sequence from 12 species, all derived from the genomic region orthologous to a segment of about 1.8 Mb on human chromosome 7 containing ten genes, show conservation reflecting both functional constraints and the neutral mutational events that shaped this genomic region.

TL;DR: This human proof-of-concept study demonstrates systemic administration of a hydrophilic medication by MN-enhanced TD delivery and set the stage for future human studies of skin-impermeant medications and biopharmaceuticals for clinical applications.

TL;DR: Overall, this study showed that pre-treatment of skin with microneedles before applying an occlusive transdermal patch can increase skin permeability for more than one day, but nonetheless allow skin to reseal rapidly after patch removal.

TL;DR: Over the course of the study period, VRC01-lineage clades showed continuous evolution, with rates of ∼2 substitutions per 100 nucleotides per year, comparable to that of HIV-1 evolution.