S
Stephen D. Mastrian
Researcher at Translational Genomics Research Institute
Publications - 13
Citations - 1526
Stephen D. Mastrian is an academic researcher from Translational Genomics Research Institute. The author has contributed to research in topics: Genome & Exome. The author has an hindex of 9, co-authored 13 publications receiving 1432 citations. Previous affiliations of Stephen D. Mastrian include National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Comparative analyses of multi-species sequences from targeted genomic regions
James W. Thomas,James W. Thomas,Jeffrey W. Touchman,Robert W. Blakesley,Gerry Bouffard,Stephen M. Beckstrom-Sternberg,Elliott H. Margulies,Mathieu Blanchette,Adam Siepel,Pamela J. Thomas,Jenny McDowell,Baishali Maskeri,Nancy F. Hansen,M. S. Schwartz,R. J. Weber,W. J. Kent,Donna Karolchik,T. C. Bruen,R. Bevan,David J. Cutler,Scott Schwartz,Laura Elnitski,Jacquelyn R. Idol,Arjun B. Prasad,Shih-Queen Lee-Lin,Valerie Maduro,Tyrone J. Summers,Matthew E. Portnoy,Nicole Dietrich,N. Akhter,K. Ayele,Betty Benjamin,K. Cariaga,Charles P. Brinkley,Shelise Brooks,S. Granite,Xin-Yuan Guan,Jyoti Gupta,P. Haghighi,S. L. Ho,M. C. Huang,Eric Karlins,P. L. Laric,Richelle Legaspi,M. J. Lim,Quino Maduro,Cathy Masiello,Stephen D. Mastrian,J. C. McCloskey,R. Pearson,Sirintorn Stantripop,Emmanuelle Tiongson,J. T. Tran,C. Tsurgeon,Jennifer Vogt,M. A. Walker,Keith Wetherby,L. S. Wiggins,Alice C. Young,L. H. Zhang,Kazutoyo Osoegawa,Baoli Zhu,B. Zhao,C. L. Shu,P. J. De Jong,Charles E. Lawrence,Arian F.A. Smit,Aravinda Chakravarti,David Haussler,Philip Green,Webb Miller,Eric D. Green +71 more
TL;DR: The generation and analysis of over 12 megabases of sequence from 12 species, all derived from the genomic region orthologous to a segment of about 1.8 Mb on human chromosome 7 containing ten genes, show conservation reflecting both functional constraints and the neutral mutational events that shaped this genomic region.
Journal ArticleDOI
Integrated Genomic Characterization Reveals Novel, Therapeutically Relevant Drug Targets in FGFR and EGFR Pathways in Sporadic Intrahepatic Cholangiocarcinoma
Mitesh J. Borad,Mia D. Champion,Jan B. Egan,Winnie S. Liang,Rafael Fonseca,Alan H. Bryce,Ann E. McCullough,Michael T. Barrett,Michael T. Barrett,Katherine S. Hunt,Maitray D. Patel,Scott W. Young,Joseph M. Collins,Alvin C. Silva,Rachel M. Condjella,Matthew S. Block,Robert R. McWilliams,Konstantinos N. Lazaridis,Eric W. Klee,Keith C. Bible,Pamela E. Harris,Gavin R. Oliver,Jaysheel D. Bhavsar,Asha Nair,Sumit Middha,Yan W. Asmann,Jean Pierre A. Kocher,Kimberly A. Schahl,Benjamin R. Kipp,Emily G. Barr Fritcher,Angela Baker,Jessica Aldrich,Ahmet Kurdoglu,Tyler Izatt,Alexis Christoforides,Irene Cherni,Sara Nasser,Rebecca Reiman,Lori Phillips,Jackie McDonald,Jonathan Adkins,Stephen D. Mastrian,Pamela Placek,Aprill Watanabe,Janine LoBello,Haiyong Han,Daniel D. Von Hoff,Daniel D. Von Hoff,David Craig,A. Keith Stewart,John D. Carpten +50 more
TL;DR: FGFR2 fusions and ERRFI mutations may represent novel targets in sporadic intrahepatic cholangiocarcinoma and trials should be characterized in larger cohorts of patients with these aberrations.
Journal ArticleDOI
Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina
Wesley D. Swingley,Min Chen,Patricia C. Cheung,Amber L. Conrad,Liza C. Dejesa,Jicheng Hao,Barbara M. Honchak,Lauren E. Karbach,Ahmet Kurdoglu,Surobhi Lahiri,Stephen D. Mastrian,Hideaki Miyashita,Lawrence E. Page,Pushpa Ramakrishna,Soichirou Satoh,W. Matthew Sattley,Yuichiro Shimada,Heather L. Taylor,Tatsuya Tomo,Tohru Tsuchiya,Zi T. Wang,Jason Raymond,Mamoru Mimuro,Robert E. Blankenship,Jeffrey W. Touchman,Jeffrey W. Touchman +25 more
TL;DR: Key features of the complete genome of A. marina show that the genus Acaryochloris is a fitting candidate for understanding genome expansion, gene acquisition, ecological adaptation, and photosystem modification in the cyanobacteria.
Journal ArticleDOI
The Complete Genome Sequence of Roseobacter denitrificans Reveals a Mixotrophic Rather than Photosynthetic Metabolism
Wesley D. Swingley,Sumedha Sadekar,Stephen D. Mastrian,Heather J. Matthies,Jicheng Hao,Hector Ramos,Chaitanya R. Acharya,Amber L. Conrad,Heather L. Taylor,Liza C. Dejesa,Maulik K. Shah,Maeve O'Huallachain,Michael T. Lince,Robert E. Blankenship,J. Thomas Beatty,Jeffrey W. Touchman,Jeffrey W. Touchman +16 more
TL;DR: The complete genomic sequence and feature analysis of the AAP Roseobacter denitrificans are presented, which reveal clues to its physiology and describe the potential importance of mixotrophic rather than autotrophic CO2 fixation pathways in these organisms.
Journal ArticleDOI
The Genome of Heliobacterium modesticaldum, a Phototrophic Representative of the Firmicutes Containing the Simplest Photosynthetic Apparatus
W. Matthew Sattley,Michael T. Madigan,Wesley D. Swingley,Patricia C. Cheung,Kate M. Clocksin,Amber L. Conrad,Liza C. Dejesa,Barbara M. Honchak,Deborah O. Jung,Lauren E. Karbach,Ahmet Kurdoglu,Surobhi Lahiri,Stephen D. Mastrian,Lawrence E. Page,Heather L. Taylor,Zi T. Wang,Jason Raymond,Min Chen,Robert E. Blankenship,Jeffrey W. Touchman,Jeffrey W. Touchman +20 more
TL;DR: The complete genome sequence of H. modesticaldum reveals an organism with a notable degree of metabolic specialization and genomic reduction, in contrast to the nutritional flexibility of many anoxygenic phototrophs.