Gerry Bouffard

TL;DR: The ENCyclopedia Of DNA Elements (ENCODE) Project is organized as an international consortium of computational and laboratory-based scientists working to develop and apply high-throughput approaches for detecting all sequence elements that confer biological function.

TL;DR: In this article, the authors performed systematic chromatin and transcriptome profiling in human pancreatic islets and found that stretch enhancers are critical chromatin elements for coordinating cell type-specific regulatory programs.

TL;DR: The generation and analysis of over 12 megabases of sequence from 12 species, all derived from the genomic region orthologous to a segment of about 1.8 Mb on human chromosome 7 containing ten genes, show conservation reflecting both functional constraints and the neutral mutational events that shaped this genomic region.

TL;DR: Over the course of the study period, VRC01-lineage clades showed continuous evolution, with rates of ∼2 substitutions per 100 nucleotides per year, comparable to that of HIV-1 evolution.

TL;DR: A genomic study of a polyclonal outbreak of multidrug-resistant A. baumannii found the simultaneous presence of three divergent strains from this lineage supports its increasing prevalence in international hospitals and suggests an ongoing adaptation to the hospital environment.