Urban Lendahl

TL;DR: Functional similarity data show that endoproteolysis, NTF–CTF interactions, and the assembly and activity of γ‐secretase complexes are very conserved between PS1 and PS2.

TL;DR: A gene (SEQ ID NO: 1 or SEQ ID No: 3) encoding a protein, nestin, whose expression distinguishes neural multipotential stem cells and brain tumor cells from the more differentiated neural cell types (e.g., neuronal, glial and muscle cells) as mentioned in this paper.

TL;DR: Although the CSF levels of Nestin expression did not change with increasing GA, the asphyxia group had significantly lower levels of nestin in theCSF, and an unexpected finding was that brain-derived nestin had an apparent molecular mass of approximately 240 kD, whereas all analyzed CSF samples contained two nestin-immunoreactive proteins at 200 and 220 kD.

TL;DR: A ratNT-4 gene fragment, containing all exons and introns in addition to 1.4 kb of the upstream genomic sequence, has been introduced into mice and enables partial recapitulation of the expression pattern of NT-4 mRNA and confers activity-dependent expression of the NT- 4 mRNA in muscle.

TL;DR: In this article, an ependymal neural CNS stem cell is defined as a cell which can express the surface protein Notch 1 together with at least one surface protein chosen from the group of Notch 2, Notch 3, CAR (transmembrane protein binding adenovirus) and CFTR (cystic fibrosis transmembane conductance regulator).