Urban Lendahl

TL;DR: Molecular insights into how reduced oxygen levels control the cellular differentiation status are provided and a role for Notch is demonstrated in this process.

TL;DR: Recent studies in nematodes, Drosophila and vertebrate systems that begin to shed light on how versatility in Notch signaling output is generated, how signal strength is modulated, and how cross-talk between the Notch pathway and other intracellular signaling systems, such as the Wnt, hypoxia and BMP pathways, contributes to signaling diversity.

TL;DR: A complex integration of the hypoxia and Notch signaling pathways in regulation of EMT is demonstrated and perspectives for pharmacological intervention with hypoxiainduced EMT and cell invasiveness in tumors are opened up.

TL;DR: In transgenic mice, independent cell type-specific elements in the first and second introns of the nestin gene consistently direct reporter gene expression to developing muscle and neural precursors, respectively, suggesting that there may be a single transcriptional mechanism regulating the CNS stem cell state.

TL;DR: The current understanding of how Notch signaling can become derailed, either by direct mutations or by aberrant regulation, and the expanding spectrum of diseases and cancers that is a consequence of Notch dysregulation are discussed.