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Urban Lendahl
Researcher at Karolinska Institutet
Publications - 242
Citations - 31645
Urban Lendahl is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Notch signaling pathway & Nestin. The author has an hindex of 79, co-authored 228 publications receiving 28639 citations. Previous affiliations of Urban Lendahl include University of Hong Kong & Åbo Akademi University.
Papers
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Journal ArticleDOI
Notch signalling regulates epibranchial placode patterning and segregation.
Li Wang,Junjie Xie,Haoran Zhang,Long Hin Tsang,Sze Lan Tsang,Eike-Benjamin Braune,Urban Lendahl,Mai Har Sham +7 more
TL;DR: Notch signalling regulates the rostral-caudal patterning and commitment of the epibranchial placodal region into repeated Vgll2/Irx5+ and Sox2+/Fgf3+/Etv5+ domains along the pharyngeal clefts, leading to the formation of individual placodes.
Patent
Nestin expression as an indicator of neuroepithelial tumors
Ronald D.G. McKay,Urban Lendahl +1 more
TL;DR: A gene encoding a protein, nestin, whose expression distinguishes neural multipotential stem cells and brain tumor cells from the more differentiated neural cell types (e.g., neuronal, glial and muscle cells) is also described as discussed by the authors.
Journal ArticleDOI
Mouse Serrate-1 and Notch genes differ in their response to signaling molecules during odontogenesis
TL;DR: The expression and regulation of the mouse Serrate-1 (Ser-1) gene during tooth development is analysed and particular emphasis was given to tissue interactions, since it was previousry shown that such interactions and exposure to specific signaling molecules are critical in organizing the expression of Notch receptors during odontogenesis.
Journal ArticleDOI
P4-297 Functional domains in presenilin 1: the TYR-288 residue controls gamma-secretas activity and endoproteolysis
Hanna Laudon,Helena Karlstöm,Paul M. Mathews,Mark R. Farmery,Sam Gandy,Johan Lundkvist,Urban Lendahl,Jan Näslund +7 more
Journal ArticleDOI
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model
Daniel V. Oliveira,Kirsten Coupland,Shaobo Jin,Francesca Del Gaudio,Sailan Wang,Rhys Fox,Julie W. Rutten,Johan Sandin,Johan Lundkvist,Saskia A J Lesnik Oberstein,Urban Lendahl,Helena Karlström +11 more
TL;DR: This is the first therapeutic study reporting a successful reduction of CADASIL-like NOTCH3 accumulation in mice, supporting further development towards clinical application for the benefit of CADasIL patients.