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Urban Lendahl
Researcher at Karolinska Institutet
Publications - 242
Citations - 31645
Urban Lendahl is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Notch signaling pathway & Nestin. The author has an hindex of 79, co-authored 228 publications receiving 28639 citations. Previous affiliations of Urban Lendahl include University of Hong Kong & Åbo Akademi University.
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Journal ArticleDOI
Notch signaling promotes a HIF2α-driven hypoxic response in multiple tumor cell types
Anders P. Mutvei,Sebastian K.-J. Landor,Sebastian K.-J. Landor,Rhys Fox,Eike-Benjamin Braune,Yat Long Tsoi,Yee Peng Phoon,Cecilia Sahlgren,Johan Hartman,Jonas Bergh,Shaobo Jin,Urban Lendahl +11 more
TL;DR: It is reported that Notch signaling specifically controls expression of HIF2α, a key mediator of the cellular hypoxic response, which may be important for future cancer therapies.
Journal ArticleDOI
Frequency and distribution of Notch mutations in tumor cell lines
TL;DR: The higher mutation frequency in tumor cell lines indicates that Notch mutations are associated with a growth advantage in vitro, and thus may be considered to be driver mutations in a tumor cell line context.
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Identification, discrimination and heterogeneity of fibroblasts
TL;DR: Fibroblasts, the principal cell type of connective tissue, secrete extracellular matrix components during tissue development, homeostasis, repair and disease as discussed by the authors .
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Functional Domains in Presenilin 1 THE TYR-288 RESIDUE CONTROLS γ-SECRETASE ACTIVITY AND ENDOPROTEOLYSIS
Hanna Laudon,Helena Karlström,Paul M. Mathews,Mark R. Farmery,Sam Gandy,Johan Lundkvist,Urban Lendahl,Jan Näslund +7 more
TL;DR: In this article, the role of presenilin (PS) proteins in endoproteolysis, in proteolytic processing of APP and Notch, and in assembly of the γ-secretase complex was investigated.
Journal ArticleDOI
Publisher Correction: Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
Lars Muhl,Guillem Genové,Stefanos Leptidis,Jianping Liu,Liqun He,Liqun He,Giuseppe Mocci,Ying Sun,Sonja Gustafsson,Byambajav Buyandelger,Indira V. Chivukula,Åsa Segerstolpe,Åsa Segerstolpe,Elisabeth Raschperger,Emil M. Hansson,Johan Björkegren,Johan Björkegren,Xiao-Rong Peng,Michael Vanlandewijck,Michael Vanlandewijck,Urban Lendahl,Christer Betsholtz,Christer Betsholtz +22 more
TL;DR: An amendment to this paper has been published and can be accessed via a link at the top of the paper.