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Urban Lendahl
Researcher at Karolinska Institutet
Publications - 242
Citations - 31645
Urban Lendahl is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Notch signaling pathway & Nestin. The author has an hindex of 79, co-authored 228 publications receiving 28639 citations. Previous affiliations of Urban Lendahl include University of Hong Kong & Åbo Akademi University.
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Journal ArticleDOI
Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations
Emma R. Andersson,Indira V. Chivukula,Simona Hankeova,Simona Hankeova,Marika Sjöqvist,Yat Long Tsoi,Daniel Ramsköld,Jan Masek,Aiman Elmansuri,Anita Hoogendoorn,Elenae Vazquez,Helena Storvall,Julie Netušilová,Meritxell Huch,Meritxell Huch,Björn Fischler,Ewa Ellis,Adriana Elisa Espinoza Contreras,Antal Nemeth,Kenneth C. Chien,Hans Clevers,Rickard Sandberg,Vitezslav Bryja,Urban Lendahl +23 more
TL;DR: In mice, expression of a missense mutant of Jag1 (Jag1Ndr) disrupts bile duct development and recapitulates Alagille syndrome phenotypes in heart, eye, and craniofacial dysmorphology.
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Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates
TL;DR: The mechanisms regulating recruitment of cytosolic Drp1 to the mitochondrial outer membrane by Fis1, Mff, and MIEF1 in mammals and the divergences in regulation of mitochondrial dynamics between yeast and vertebrates are highlighted.
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Thyroid abnormalities and hepatocellular carcinoma in mice transgenic for v-erbA.
TL;DR: Transgenic mice expressing v‐erbA ubiquitously provide an animal model consistent with the proposal that v‐ErbA functions as a dominant negative receptor by transcriptional interference or squelching of normal receptors or associated proteins.
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Notch and the birth of glial cells
Johan Lundkvist,Urban Lendahl +1 more
TL;DR: This work, combined with other reports from the developing CNS, retina and the PNS, demonstrates a role for Notch in gliogenesis and can be linked to novel insights into the function of proneural basic helix-loop-helix proteins in astrocytic differentiation.
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SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation.
Johan Holmberg,Emil M. Hansson,Michal Malewicz,Magnus Sandberg,Thomas Perlmann,Urban Lendahl,Jonas Muhr +6 more
TL;DR: The data reveal that Notch signaling and SoxB1 transcription factors use distinct regulatory mechanisms to control proneural protein function and to preserve neural cells as undifferentiated precursors.