Urban Lendahl

TL;DR: It is shown that synergy between factors, as well as the use of extrinsic factors, drastically reduce the number of regulatory factors needed for recapitulating the lineage and can faithfully recapitulate the entire C. elegans cell lineage.

TL;DR: The data suggest that SARS-Cov-2 is unlikely to infect endothelial cells directly; these findings are consistent with a scenario where endothelial injury is indirectly caused by the infection of neighbouring epithelial cells and/or due to systemic effects mediated by immune cells, platelets, complement activation, and/ or proinflammatory cytokines.

TL;DR: The finding that Notch instructs gliogenesis might not be immediate good news for the attempts todifferentiate stem cells to neurons, but it might be argued that blocking Notch signaling at some level in the signaling Cascade could make cells more prone to choose a neuronal fate.