V. Sivakamasundari

TL;DR: This work found that transcriptional signatures of the cDC1 and cDC2 lineages became evident at the single-cell level from the CDP stage, and identified Siglec-H and Ly6C as lineage markers that distinguished pre-DC subpopulations committed to the c DC1 lineage (SigleC-H−Ly6C− pre- DCs) or c DC2 lineage (CDC2 lineage).

TL;DR: It is revealed that delta cells specifically express receptors that receive and coordinate systemic cues from the leptin, ghrelin, and dopamine signaling pathways implicating them as integrators of central and peripheral metabolic signals into the pancreatic islet.

TL;DR: The data suggest that treatment-resistance in SCLC is characterized by coexisting subpopulations of cells with heterogeneous gene expression leading to multiple, concurrent resistance mechanisms, which emphasize the need for clinical efforts to focus on rational combination therapies for treatment-naïve SclC tumors to maximize initial responses and counteract the emergence of ITH and diverse resistance mechanisms.

TL;DR: It is demonstrated in this comparison study that the efficient and close to equivalent expression of genes linked by F2A is achievable in stable mouse lines, but the EGFP reporter may cause undesirable inhibition of the ‘skipping’ at the F1A sequence, Hence, the use of other reporter genes should be explored when utilizing F 2A peptides.

TL;DR: The essential molecular roles of Pax1/Pax9 in early IVD development and their connection with other chrondrogenic players – Sox trio, BMP and TGF B pathways are shown.