Romy Kursawe

TL;DR: WAT-derived hepatic acetyl CoA is identified as the main regulator of HGP by insulin and link it to inflammation-induced hepatic insulin resistance associated with obesity and T2D.

TL;DR: It is revealed that delta cells specifically express receptors that receive and coordinate systemic cues from the leptin, ghrelin, and dopamine signaling pathways implicating them as integrators of central and peripheral metabolic signals into the pancreatic islet.

TL;DR: The results suggest that SirT1 regulates adipose tissue inflammation by controlling the gain of proinflammatory transcription in response to inducers such as fatty acids, hypoxia, and endoplasmic reticulum stress.

TL;DR: The rs1260326 in GCKR is associated with hepatic fat accumulation along with large VLDL and triglyceride levels and acts together with the PNPLA3 to convey susceptibility to fatty liver in obese youths.

TL;DR: A common variant of the PNPLA3 gene confers susceptibility to hepatic steatosis in obese youths without increasing the level of hepatic and peripheral insulin resistance.