Vadim A. Soloshonok

TL;DR: This method presents a general approach for the preparation of a new type of biologically relevant compounds containing pharmacophoric imidazo[2,1-b]thiazole and (trifluoro)ethylamine groups.

TL;DR: The origin of virtually complete face diastereoselectivity in the organic base-catalyzed, room temperature Michael addition reactions between Ni(II)-complexes of Schiff bases of glycine and chiral 3-( E -enoyl)-4-substituted-1,3-oxazolidin-2-ones was shown to stem from the unusual mode of steric interactions in determining the corresponding transition state as discussed by the authors.

TL;DR: In this article, a comprehensive overview of N-tert-butylsulfinyl-3,3, 3,3-trifluoroacetaldimine is presented.

TL;DR: Efficient asymmetric detrifluoroacetylative Mannich addition reactions between 2-fluoro-1,3-di-ketones/hydrates and chiral N-sulfinyl-imines via C-C bond cleavage were reported, which afforded C-F quaternary α- fluoro-β-keto-amines with excellent yields and high diastereoselectivity.

TL;DR: In this paper, a simple stirring of a biphasic mixture of the Ni(II) complex of glycine Schiff base 2 solution in dichloromethane with 30% aqueous NaOH in the presence of PT catalyst nBu4N+Br− at room temperature for 24-h results in the formation of diastereo and enantiomerically pure Ni( II) complex 3, containing (2S,4S) 4-aminoglutamic acid, in high chemical yield.