V
Vadim A. Soloshonok
Researcher at University of the Basque Country
Publications - 417
Citations - 16252
Vadim A. Soloshonok is an academic researcher from University of the Basque Country. The author has contributed to research in topics: Enantioselective synthesis & Amino acid. The author has an hindex of 64, co-authored 406 publications receiving 14170 citations. Previous affiliations of Vadim A. Soloshonok include University of Oklahoma & Centre national de la recherche scientifique.
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Large‐Scale Asymmetric Synthesis of Fmoc‐(S)‐2‐Amino‐6,6,6‐Trifluorohexanoic Acid
Zizhen Yin,Hiroki Moriwaki,Hidenori Abe,Toshio Miwa,Jianlin Han,Vadim A. Soloshonok,Vadim A. Soloshonok +6 more
TL;DR: The first large‐scale synthesis of Fmoc‐(S)‐2‐amino‐6, 6,6,6‐trifluorohexanoic acid via asymmetric alkylation of chiral Ni(II)‐complex of glycine Schiff base with CF3(CH2)3I is reported.
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Purely Chemical Approach for Preparation of d-α-Amino Acids via (S)-to-(R)-Interconversion of Unprotected Tailor-Made α-Amino Acids.
Yong Nian,Jiang Wang,Shengbin Zhou,Wenhao Dai,Shuni Wang,Hiroki Moriwaki,Aki Kawashima,Vadim A. Soloshonok,Hong Liu +8 more
TL;DR: This work presents development of a purely chemical approach for preparation of (R)-α-AAs via (S)-to-(R)-interconversion of natural and tailor-made (S), rivaling previously reported chemical and biocatalytic approaches.
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Highly Stereoselective aza‐Baylis–Hillman Reactions of CF3‐Sulfinylimines: Straightforward Access to α‐Methylene β‐CF3 β‐Amino Acids
TL;DR: The tert-butanesulfinyl group acts as chiral auxiliary and is removed after the aza-Baylis-Hillman reaction in the presence of HCl in dioxane as mentioned in this paper.
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Catalytic cascade aldol–cyclization of tertiary ketone enolates for enantioselective synthesis of keto-esters with a C–F quaternary stereogenic center
TL;DR: This reaction tolerates a wide range of substrates, affording fluorinated quaternary stereogenic α,α-dialkyl/cyclo-alkyl-β-ketoesters with good yields, high diastereo- and enantioselectivity at room temperature.
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Operationally convenient, efficient asymmetric synthesis of enantiomerically pure 4-aminoglutamic acids via methylene dimerization of chiral glycine equivalents with dichloromethane
Vadim A. Soloshonok,Takeshi Yamada,Takeshi Yamada,Hisanori Ueki,Anna M. Moore,Tanner K. Cook,Kelsey L. Arbogast,Anatolii V. Soloshonok,Collin H. Martin,Yasufumi Ohfune +9 more
TL;DR: In this paper, the authors presented a practical and efficient asymmetric synthesis of enantiomerically pure 4-aminoglutamic acids using a quite unusual methylene dimerization of chiral nucleophilic glycine equivalents with dichloromethane under phase transfer catalysis (PTC) conditions.