V
Vadim A. Soloshonok
Researcher at University of the Basque Country
Publications - 417
Citations - 16252
Vadim A. Soloshonok is an academic researcher from University of the Basque Country. The author has contributed to research in topics: Enantioselective synthesis & Amino acid. The author has an hindex of 64, co-authored 406 publications receiving 14170 citations. Previous affiliations of Vadim A. Soloshonok include University of Oklahoma & Centre national de la recherche scientifique.
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Journal ArticleDOI
Novel Sequence of Two Base-Catalyzed 1,3-Proton Shifts and [1,2]-Wittig Rearrangement in the Synthesis of 2,4-Bis-(trifluoromethyl)-6-phenylpyridine.
TL;DR: In this paper, the reaction of 1.1, 1.5, 5, 5.5-hexafluoro-2,4-pentanedione with (R)-phenylglycinol was found to proceed via intermediate formation of (R, 4E, 6Z)-5, 7-bis-(trifluoromethyl)-2, 3-dihydro-3-phenyl-1, 4-oxazepine which further underwent a base-catalyzed 1,3-proton shift reaction followed by [
Journal ArticleDOI
2,2,2-Trifluoro-1-(1-adamantyl)ethylamine Hydrochloride.
TL;DR: In this paper, a convenient synthesis of a hitherto unknown fluorinated analogue of 1-(1-adamantyl)ethylamine (remantadine) starting from readily available 1-bromoadamantane and trifluoroacetic anhydride is described.
Book ChapterDOI
Synthesis of β and γ-Substituted Prolines for Conformation-Activity Relationship Studies of the α-MSH Analogue MT-II
TL;DR: This work has synthesized a series of novel, topographically constrained β and γ-substituted prolines and incorporated these optically pure substituted prolines into MT-II at positions 6 and 7.
Journal ArticleDOI
Asymmetric Mannich Reaction Between (S)‐N‐(tert‐Butanesulfinyl)‐3,3,3‐trifluoroacetaldimine and Malonic Acid Derivatives. Stereodivergent Synthesis of (R)‐ and (S)‐3‐Amino‐4,4,4‐trifluorobutanoic Acids.
Norio Shibata,Takayuki Nishimine,Naoyuki Shibata,Etsuko Tokunaga,Kosuke Kawada,Takumi Kagawa,Jose Luis Acena,Alexander E. Sorochinsky,Alexander E. Sorochinsky,Alexander E. Sorochinsky,Vadim A. Soloshonok,Vadim A. Soloshonok +11 more
TL;DR: In this paper, the influence of the base on the diastereoselectivity of the mannich reaction and the stability of the formed dastereomers is investigated.
Journal ArticleDOI
LDA-Promoted Asymmetric Synthesis of β-Trifluoromethyl-β-amino Indanone Derivatives with Virtually Complete Stereochemical Outcome.
TL;DR: In this paper, it was shown that β-trifluoromethyl-β-amino indanone derivatives can be isolated in diastereomerically pure form simply by washing the crude reaction mixture with hexanes, underscoring practicality of the present method.