Wieslawa I. Mentzen

TL;DR: Genetic contributions to quantitative levels of 95 cell types encompassing 272 immune traits, in a cohort of 1,629 individuals from four clustered Sardinian villages are reported, connecting specific cellular phenotypes to specific genetic variants, helping to explicate their involvement in disease.

TL;DR: Results indicate that ACL, encoded by theACLA and ACLB genes of Arabidopsis, generates cytosolic acetyl-CoA, a homomeric structure indicating that a evolutionary fusion of the ACLA and ACL B genes probably occurred early in the evolutionary history of this kingdom.

TL;DR: A coexpression network from a 22,746 Affymetrix probes dataset derived from 963 microarray chips that query the transcriptome in response to a wide variety of environmentally, genetically, and developmentally induced perturbations reveals a higher-level organization, with dense local neighborhoods articulated for photosynthetic function, genetic information processing, and stress response.

TL;DR: Each of these core metabolic pathways is structured as a module of co-expressed transcripts that co-accumulate over a wide range of environmental and genetic perturbations and developmental stages, and represent an expanded set of macromolecules associated with the common task of supporting the functionality of each metabolic pathway.

TL;DR: Current progress in quantitative phosphoproteomics is described and possible improvements for analysis of quantitative phosphorylation are suggested by increasing the number of biological replicates and adapting statistical tests used for gene expression profiling and widely implemented in freely available software tools.